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65251-91-4

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65251-91-4 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 65251-91-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,5,2,5 and 1 respectively; the second part has 2 digits, 9 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 65251-91:
(7*6)+(6*5)+(5*2)+(4*5)+(3*1)+(2*9)+(1*1)=124
124 % 10 = 4
So 65251-91-4 is a valid CAS Registry Number.

65251-91-4Relevant articles and documents

New synthesis method of thiabendazole

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Paragraph 0026; 0031; 0032; 0037-0040; 0059; 0060, (2020/02/20)

The invention relates to a new synthetic route of a drug commonly named as thiabendazole. Thiazole-4-formaldehyde is used as a raw material, and is condensed with hydroxylamine hydrochloride to obtainthiazole-4-formaldoxime, thiazole-4-formaldoxime is subjected to chlorination by using NCS, and then reacts with aniline to obtain N-phenylthiazole-4-methylamine oxime, then N-phenylthiazole-4-methylamine oxime reacts with p-trifluoromethyl benzoyl chloride to obtain an amidoxime ester, and finally a visible-light-catalyzed free radical reaction is adopted for cyclization to obtain thiazole. According to the method, the visible-light-catalyzed free radical reaction is used to the synthesis of thiabendazole for the first time, the reaction conditions of a high temperature and a strong acid inthe traditional synthesis method are avoided, and thereby the reaction is greener and milder. The method has a broad spectrum, and can also be used for synthesis of imidazole compounds Ia-Ial.

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