65251-91-4

Basic information

• Product Name: 2-CHLORO-N'-HYDROXY-N-PHENYLBENZENECARBOXIMIDAMIDE
• Synonyms: 2-CHLORO-N'-HYDROXY-N-PHENYLBENZENECARBOXIMIDAMIDE;(Z)-2-chloro-N'-hydroxy-N-phenylbenzene-1-carboximidamide
• CAS NO: 65251-91-4
• Molecular Formula: C₁₃H₁₁ClN₂O
• Molecular Weight: 246.69
• Mol File: 65251-91-4.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-CHLORO-N'-HYDROXY-N-PHENYLBENZENECARBOXIMIDAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CHLORO-N'-HYDROXY-N-PHENYLBENZENECARBOXIMIDAMIDE(65251-91-4)
• EPA Substance Registry System: 2-CHLORO-N'-HYDROXY-N-PHENYLBENZENECARBOXIMIDAMIDE(65251-91-4)

Safety Data

• Hazardous Substances Data: 65251-91-4(Hazardous Substances Data)

Upstream product

• 62-53-3 aniline 
• 29568-74-9 2-chloro-N-hydroxybenzimidoyl chloride 

Downstream Products

• 86339-22-2 C₂₀H₁₅ClN₂O₂ 
• 3574-96-7 2-(2-chlorophenyl)-1H-benzimidazole 

Relevant articles and documents

New synthesis method of thiabendazole

The invention relates to a new synthetic route of a drug commonly named as thiabendazole. Thiazole-4-formaldehyde is used as a raw material, and is condensed with hydroxylamine hydrochloride to obtainthiazole-4-formaldoxime, thiazole-4-formaldoxime is subjected to chlorination by using NCS, and then reacts with aniline to obtain N-phenylthiazole-4-methylamine oxime, then N-phenylthiazole-4-methylamine oxime reacts with p-trifluoromethyl benzoyl chloride to obtain an amidoxime ester, and finally a visible-light-catalyzed free radical reaction is adopted for cyclization to obtain thiazole. According to the method, the visible-light-catalyzed free radical reaction is used to the synthesis of thiabendazole for the first time, the reaction conditions of a high temperature and a strong acid inthe traditional synthesis method are avoided, and thereby the reaction is greener and milder. The method has a broad spectrum, and can also be used for synthesis of imidazole compounds Ia-Ial.