65253-72-7Relevant academic research and scientific papers
Base-Induced Cyclization of Active Methylene Isocyanides with Xanthate Esters: An Efficient Method for the Synthesis of 5-Alkoxy-4-(tosyl/ethoxycarbonyl)-1,3-thiazoles
Rajeev, Narasimhamurthy,Swaroop, Toreshettahally R.,Anil, Seegehalli M.,Bommegowda, Yadaganahalli K.,Rangappa, Kanchugarakoppal S.,Sadashiva, Marilinganadoddi P.
, p. 2281 - 2284 (2017)
Sodium hydride-induced cyclization of 1-[(isocyanomethyl)sulfonyl]-4-methylbenzene or ethyl isocyanoacetate with various xanthate esters gave 5-alkoxy-4-tosylthiazoles or ethyl 5-alkoxythiazol-4-ylcarboxylates, respectively, in good to excellent yields. The xanthate ester S -methyl O -phenyl dithiocarbonate gave 5-(methylsulfanyl)-4-tosyl-1,3-thiazole when treated with 1-[(isocyanomethyl)sulfonyl]-4-methylbenzene under similar conditions.
