652538-99-3

Upstream product

• 54346-27-9 4-oxo-3H-pyrazolo<1,5-a>-1,3,5-triazine 
• 100-61-8 N-methylaniline 
• 54346-27-9 1H,4H-pyrazolo[1,5-a][1,3,5]triazin-4-one 

Downstream Products

• 934524-86-4 N-[2-(2,2-diphenyl-1,3-benzodioxol-5-yl)ethyl]-3-(3,4-dihydro-4-oxopyrazolo[1,5-a]-1,3,5-triazin-8-yl)propionamide 
• 934524-83-1 N-[2-(2,2-diphenyl-1,3-benzodioxol-5-yl)ethyl]-3-[4-(N-methyl-N-phenylamino)pyrazolo[1,5-a]-1,3,5-triazin-8-yl]propionamide 
• 934524-82-0 N-[3-(2-oxopyrrolidin-1-yl)propyl]-3-[4-(N-methyl-N-phenylamino)pyrazolo[1,5-a]-1,3,5-triazin-8-yl]propionamide 
• 652538-77-7 N-(4-methoxycarbonylphenyl)-3-[4-(N-methyl-N-phenylamino)pyrazolo[1,5-a]-1,3,5-triazin-8-yl]propionamide 
• 652538-76-6 3-[4-(N-methyl-N-phenylamino)pyrazolo[1,5-a]-1,3,5-triazin-8-yl]propionic acid 
• 934524-88-6 tert-butyl 3-[4-(N-methyl-N-phenylamino)pyrazolo[1,5-a]-1,3,5-triazin-8-yl]propanoate 
• 652539-01-0 8-iodo-4-(N-methyl-N-phenylamino)pyrazolo[1,5-a]-1,3,5-triazine 

Relevant academic research and scientific papers

Pyrazolo[1,5- a ]-1,3,5-triazine C-nucleoside as deoxyadenosine analogue: Synthesis, pairing, and resistance to hydrolysis

The synthesis of a pyrazolo[1,5-a]-1,3,5-triazine C-nucleoside (dA PT), designed to form two hydrogen bonds with a complementary dT residue, is reported. Oligonucleotides including this dA nucleoside analogue possess base-pairing properties similar to those of the parent oligonucleotide. This dA nucleoside analogue is more resistant to acid-catalyzed hydrolysis than dA.

MLL1 INHIBITORS AND ANTI-CANCER AGENTS

The present invention provides a compound of Formula (I): or an enantiomer, an enantiomeric mixture, or a pharmaceutically acceptable salt thereof; wherein the variables are as defined herein. The present invention further provides pharmaceutical composit

Synthesis of 8-substituted pyrazolo[1,5-a]-1,3,5-triazine derivatives by palladium-catalyzed cross-coupling reactions

8-Substituted pyrazolo[1,5-a]-1,3,5-triazine derivatives 6 were prepared from the corresponding 8-iodopyrazolo[1,5-a]-1,3,5-triazines 5 through palladium-catalyzed cross-coupling reactions. Several bioisosteres of hypoxanthine drugs 2 were then prepared b

Novel substituted pyrazolo[1,5 a]-1,3,5-triazine derivatives and their analogues, pharmaceutical compositions containing same, use thereof as medicine and methods for preparing same

The invention concerns novel substituted pyrazolo[1,5 A]-1,3,5-triazine derivatives and some of their structural analogues, and their therapeutic uses, more particularly for preventing and treating pathologies involving central and/or peripheral neuronal degeneration. The invention also concerns methods for preparing same and novel synthesis intermediates. The compounds of the invention correspond more particularly to general formulae (Ia) and (Ib).