65266-66-2Relevant academic research and scientific papers
Selective reduction of peptidic ergot alkaloids
Cvak, Ladislav,Stuchlik, Josef,Schreiberova, Magdalena,Sedmera, Petr,Havlicek, Vladimir,Flieger, Miroslav,Cejka, Jan,Kratochvi'l, Bohumil,Jegorov, Alexandr
, p. 1762 - 1776 (2000)
Five 6′-deoxoergopeptines were prepared in 51-68% yield by selective reduction of parent alkaloids with lithium aluminium hydride in tetrahydrofuran at low temperature. New compounds were characterized by mass spectrometry and NMR spectroscopy. The conformation of the peptide part in starting compounds and reduced derivatives is discussed on the basis of crystal structure determination of 6′-deoxo-9,10-dihydroergotamine dihydrate butan 2-one solvate as a representative member of the series.
