65296-80-2

Basic information

• Product Name: platinum(2+) cyclohexane-1,2-diyldiazanide - benzene-1,2-dicarboxylic acid (1:1:1)
• CAS NO: 65296-80-2
• Molecular Formula: C₁₄H₁₈N₂O₄Pt
• Molecular Weight: 473.3877
• Mol File: 65296-80-2.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 378.3°C at 760 mmHg
• Flash Point: 196.7°C
• Vapor Pressure: 2.14E-06mmHg at 25°C
• CAS DataBase Reference: platinum(2+) cyclohexane-1,2-diyldiazanide - benzene-1,2-dicarboxylic acid (1:1:1)(CAS DataBase Reference)
• NIST Chemistry Reference: platinum(2+) cyclohexane-1,2-diyldiazanide - benzene-1,2-dicarboxylic acid (1:1:1)(65296-80-2)
• EPA Substance Registry System: platinum(2+) cyclohexane-1,2-diyldiazanide - benzene-1,2-dicarboxylic acid (1:1:1)(65296-80-2)

Safety Data

• Hazardous Substances Data: 65296-80-2(Hazardous Substances Data)

Upstream product

• 1121-22-8 trans-1,2-Diaminocyclohexane 
• 88-99-3 benzene-1,2-dicarboxylic acid 
• 15656-86-7 barium phthalate 
• 38780-40-4 {(1R,2R)-cyclohexane-1,2-diamine}dichloridoplatinum(II) 

Relevant articles and documents

Design, synthesis and in-vitro cytotoxicity of novel platinum (II) complexes with phthalate as the leaving group

Three platinum (II) complexes (6-8) with phthalate as the leaving group were synthesized and characterized by FTIR, 1H NMR, 13C NMR, mass spectrometry and elemental analysis. In-vitro cytotoxicity of all three complexes was evaluated using COLO 205 (human colon cancer cell line) against the parent drug "oxaliplatin". The compound 4-amino-(transcyclohexane-1,2-diamine) platinum(II) (8) showed potent cytotoxicity with IC50 = 0.12 μM as compared to oxaliplatin (IC50 = 0.19 μM) and its aqueous solubility was found to be 16 mg/mL which is higher than oxaliplatin (8 mg/mL). The acute toxicity showed that the platinum complex (8) was less toxic than oxaliplatin. Molecular oxaliplatin-DNA complex structure indicates that the diaminocyclohexane (DACH) and Pt (II) showed interactions with N7 and O6 of GG base pairs of DNA helix. In this present study, it is interesting to note that all three platinum based anticancer agents with phthalate as the leaving group exhibited great cytotoxicity, less toxicity, good lipophilicity as well as better aqueous solubility. 2013 Bentham Science Publishers.