652976-27-7

Basic information

• Product Name: (Z)-ETHYL 5-HYDROXY-8-OXO-8,9-DIHYDRO-7H-PYRIDO[2,3-B]AZEPINE-6-CARBOXYLATE
• Synonyms: (Z)-ETHYL 5-HYDROXY-8-OXO-8,9-DIHYDRO-7H-PYRIDO[2,3-B]AZEPINE-6-CARBOXYLATE
• CAS NO: 652976-27-7
• Molecular Formula: C12H12N2O4
• Molecular Weight: 248.23
• Mol File: 652976-27-7.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (Z)-ETHYL 5-HYDROXY-8-OXO-8,9-DIHYDRO-7H-PYRIDO[2,3-B]AZEPINE-6-CARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: (Z)-ETHYL 5-HYDROXY-8-OXO-8,9-DIHYDRO-7H-PYRIDO[2,3-B]AZEPINE-6-CARBOXYLATE(652976-27-7)
• EPA Substance Registry System: (Z)-ETHYL 5-HYDROXY-8-OXO-8,9-DIHYDRO-7H-PYRIDO[2,3-B]AZEPINE-6-CARBOXYLATE(652976-27-7)

Safety Data

• Hazardous Substances Data: 652976-27-7(Hazardous Substances Data)

Usage

General Description

(Z)-ETHYL 5-HYDROXY-8-OXO-8,9-DIHYDRO-7H-PYRIDO[2,3-B]AZEPINE-6-CARBOXYLATE is a chemical compound that belongs to the class of pyridoazepine derivatives. It is also known as etodolac, which is a nonsteroidal anti-inflammatory drug (NSAID) that is used to reduce pain and inflammation in conditions such as arthritis. Its chemical structure consists of a pyridoazepine ring with a carboxylate ester and a hydroxy and oxo substituent at specific positions. It acts by inhibiting the synthesis of prostaglandins, which are mediators of pain and inflammation.(Z)-ETHYL 5-HYDROXY-8-OXO-8,9-DIHYDRO-7H-PYRIDO[2,3-B]AZEPINE-6-CARBOXYLATE is commonly used as a prescription medication for various types of arthritis and acute pain.

Upstream product

• 13362-26-0 2-aminopyridine-3-carboxylic acid ethyl ester 
• 123-25-1 succinic acid diethyl ester 
• 5345-47-1 2-aminopyridin-3-carboxylic acid 

Downstream Products

• 652976-28-8 6,7,8,9-tetrahydro-5H-pyrido[2,3-b]azepine-5,8-dione 

Relevant articles and documents

1-Azakenpaullone is a selective inhibitor of glycogen synthase kinase-3β

Kenpaullone derivatives with a modified parent ring system were synthesized in order to develop kinase inhibitors with enhanced selectivity. Among the novel structures, 1-azakenpaullone was found to act as a selective GSK-3β versus CDK1 inhibitor. The charge distribution within the 1-azakenpaullone molecule is discussed as a possible explanation for the enhanced GSK-3β selectivity of 1-azakenpaullone compared to other paullone derivatives.

9- and 11-substituted 4-azapaullones are potent and selective inhibitors of African trypanosoma

Trypanosomes from the "brucei" complex are pathogenic parasites endemic in sub-Saharan Africa and causative agents of severe diseases in humans and livestock. In order to identify new antitrypanosomal chemotypes against African trypanosomes, 4-azapaullone