652985-62-1

Upstream product

• 121-60-8 p-acetylaminobenzenesulfonyl chloride 
• 21568-87-6 2-aminocaprolactam 
• 359781-82-1 Nα-Isobutyl-Nε-benzyloxycarbonyl-L-lysine Benzyl Ester 
• 24458-14-8 Lys(Z)-OBzl 
• 359782-00-6 (3S)-3-isobutylamino-azepan-2-one 
• 449806-97-7 Nα-isobutyl-Nα-(4-acetamidobenzenesulfonyl)-L-α-amino-ε-caprolactam 
• 359780-69-1 (S)-6-Benzyloxycarbonylamino-2-[isobutyl-(4-nitro-benzenesulfonyl)-amino]-hexanoic acid benzyl ester 

Downstream Products

• 500221-64-7 {5-[(4-amino-benzenesulfonyl)-isobutyl-amino]-6-hydroxy-hexyl}-carbamic acid 9H-fluoren-9-ylmethyl ester 
• 449806-99-9 (1S)-4-amino-N-(5-amino-1-hydroxymethyl-pentyl)-N-isobutyl-benzenesulfonamide 
• 449806-88-6 Nα-(4-aminobenzenesulfonyl)-Nα-isobutyl-L-lysine methyl ester 

Relevant academic research and scientific papers

Lysine sulfonamides as novel HIV-protease inhibitors: Nε-disubstituted ureas

A series of lysine sulfonamide analogues bearing a Nε-benzylic ureas was synthesized using both solution-phase and solid-phase approaches. A novel synthetic route of Nα-(alkyl)-Nα-(sulfonamides)lysinol using α-amino-caprolactam was developed. Evaluation of these novel protease inhibitors revealed compounds with high potency against wild-type HIV virus.

Lysine sulfonamides as novel HIV-Protease inhibitors: Optimization of the Nε-acyl-phenyl spacer

A series of Nα-isobutyl-Nα-arylsulfonamido-(Nε acyl) lysine and lysinol derivatives were prepared and evaluated as inhibitors of HIV protease and wild type virus. A simple original synthesis was devised to form Nα-(arylsulfonamide)-Nα-isobutyl lysine, whi