652985-95-0

Basic information

• Product Name: 7-(tetrahydro-2H-pyran-2-yl)-4-(3,4-dimethoxyphenethyl)-3-hydroxy-2-methyl-3,4-dihydro-2H-pyridazino[4,5-b][1,4]oxazine-8(7H)-one
• Synonyms: 7-(tetrahydro-2H-pyran-2-yl)-4-(3,4-dimethoxyphenethyl)-3-hydroxy-2-methyl-3,4-dihydro-2H-pyridazino[4,5-b][1,4]oxazine-8(7H)-one
• CAS NO: 652985-95-0
• Molecular Weight: 431.489
• Mol File: 652985-95-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 7-(tetrahydro-2H-pyran-2-yl)-4-(3,4-dimethoxyphenethyl)-3-hydroxy-2-methyl-3,4-dihydro-2H-pyridazino[4,5-b][1,4]oxazine-8(7H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 7-(tetrahydro-2H-pyran-2-yl)-4-(3,4-dimethoxyphenethyl)-3-hydroxy-2-methyl-3,4-dihydro-2H-pyridazino[4,5-b][1,4]oxazine-8(7H)-one(652985-95-0)
• EPA Substance Registry System: 7-(tetrahydro-2H-pyran-2-yl)-4-(3,4-dimethoxyphenethyl)-3-hydroxy-2-methyl-3,4-dihydro-2H-pyridazino[4,5-b][1,4]oxazine-8(7H)-one(652985-95-0)

Safety Data

• Hazardous Substances Data: 652985-95-0(Hazardous Substances Data)

Upstream product

• 645405-18-1 4-chloro-5-hydroxy-2-(tetrahydro-2H-pyran-2-yl)-3(2H)-pyridazinone 
• 173206-12-7 4-chloro-5-methoxy-2-(tetrahydro-2H-pyran-2-yl)-3(2H)-pyridazinone 
• 173206-13-8 4,5-dichloro-2-(tetrahydro-2H-pyran-2-yl)-3(2H)-pyridazinone 
• 110-87-2 3,4-dihydro-2H-pyran 
• 652985-94-9 7-(tetrahydro-2H-pyran-2-yl)-4-(3,4-dimethoxyphenethyl)-2-methyl-2H-pyridazino[4,5-b][1,4]oxazine-3,8(4H,7H)-dione 

Relevant articles and documents

Synthetic studies on isoquinoline derivatives with multidrug resistance (MDR) modulating activity

Tetrahydropyridazino-1,4-oxazinoisoquinoline derivatives with multidrug Resist. (MDR) modulating activity were designed and synthesized. A key step for cyclization of 1,4-oxazine ring was developed using K2CO3 and CH3CN in one-pot. Among prepared compounds, 2-(4-fluorobenzyl)-9,10-dimethoxy-12-methyl-6,7,11b,12-tetrahydropyridazino[4', 5',5,6] [1,4]oxazine-[3,4,-a]isoquinolin-1(2H)-one (1f) exhibited significant MDR reversing activity and low toxicity, which might be as potential MDR agent.