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Usage

Uses

Used in Organic Chemistry:
2-(pyridin-3-yl)-3,4-dihydronaphthalen-1(2H)-one is used as a key intermediate in the synthesis of various organic compounds for research and development purposes. Its unique structure allows for the creation of new molecules with potential applications in different industries.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, 2-(pyridin-3-yl)-3,4-dihydronaphthalen-1(2H)-one is used as a building block for the development of new pharmaceuticals. Its chemical properties make it a valuable component in the design and synthesis of novel drug candidates.
Used in Drug Discovery:
2-(pyridin-3-yl)-3,4-dihydronaphthalen-1(2H)-one is utilized in drug discovery as a potential lead compound. Its chemical and biological properties are being investigated for the development of new therapeutic agents, particularly in the pharmaceutical industry.
Used in Pharmaceutical Industry:
2-(pyridin-3-yl)-3,4-dihydronaphthalen-1(2H)-one is used as a starting material for the production of various pharmaceuticals. Its potential biological activities and chemical properties make it a promising candidate for the development of new drugs to treat various diseases and medical conditions.

Upstream product

• 6529-39-1 4-phenyl-2-(pyridin-3-yl)butyric acid 
• 6443-85-2 3-pyridinylacetonitrile 
• 6529-37-9 4-phenyl-2-(pyridin-3-yl)butyronitrile 
• 103-63-9 1-phenyl-2-bromoethane 

Downstream Products

• 93008-02-7 1-methyl-2-pyridin-3-yl-1,2,3,4-tetrahydronaphthalen-1-ol 
• 93406-29-2 1-ethyl-2-(pyridin-3-yl)-1,2,3,4-tetrahydronaphthalen-1-ol 
• 3614-50-4 3-<1-Methyl-3.4-dihydro-naphthyl-(2)>-pyridin 
• 83-33-0 inden-1-one 

Relevant academic research and scientific papers

Synthesis and evaluation of heteroaryl-substituted dihydronaphthalenes and indenes: Potent and selective inhibitors of aldosterone synthase (CYP11B2) for the treatment of congestive heart failure and myocardial fibrosis

In this study, the synthesis and biological evaluation of heteroaryl-substituted dihydronaphthalenes and indenes (1-16) is described. The compounds were tested for activity by use of human CYP11B2 expressed in fission yeast and V79 MZh cells and for selectivity by use of human CYP11B1, CYP17, and CYP19. The most active inhibitor was the 6-methoxydihydronaphthalene 4 (IC 50 = 2 nM), showing a Ki value of 1.3 nM and a competitive type of inhibition. The 5-methoxyindene 3 was found to be the most selective CYP11B2 inhibitor (IC50 = 4 nM; CYP11B1 IC50 = 5684 nM), which also showed only marginal inhibition of human CYP3A4 and CYP2D6. Docking and molecular dynamics studies using our homology-modeled CYP11B2 structure were performed to understand some structure-activity relationships. Caco-2 cell experiments revealed highly cell-permeable compounds, and metabolic studies with 4 using rat liver microsomes showed sufficient stability.

A novel class of potential central nervous system agents. 3-Phenyl-2-(1-piperazinyl)-5H-1-benzazepines

A series of 3-phenyl-2-piperazinyl-5H-1-benzazepines and related compounds were synthesized and evaluated for potential neuroleptic activity. The preparation of these compounds was carried out by 2,3-dichlorination of 3-phenyl-2,3,4,5-tetrahydro-1H-1-benz