65304-44-1Relevant academic research and scientific papers
Gold(I)-Catalyzed Highly Diastereo- and Enantioselective Cyclization–[4+3] Annulation Cascades between 2-(1-Alkynyl)-2-alken-1-ones and Anthranils
Chao, Tzu-Hsuan,Cheng, Mu-Jeng,Kardile, Rahul Dadabhau,Liu, Rai-Shung
supporting information, p. 10396 - 10400 (2020/04/29)
This work reports gold-catalyzed [4+3]-annulations of 2-(1-alkynyl)-2-alken-1-ones with anthranils to yield epoxybenzoazepine products with excellent exo-diastereoselectivity (dr>25:1). The utility of this new gold catalysis is manifested by applicable substrates over a broad scope. More importantly, the enantioselective versions of these [4+3]-cycloadditions have been developed satisfactorily with chiral gold catalysts under ambient conditions (DCM, 0 °C); the ee levels range from 88.0–99.9 %. With DFT calculations, we postulate a stepwise pathway to rationalize the preferable exo-stereoselection.
Organocatalytic Formation of Chiral Trisubstituted Allenes and Chiral Furan Derivatives
Poulsen, Pernille H.,Li, Yang,Lauridsen, Vibeke H.,J?rgensen, Danny K. B.,Palazzo, Teresa A.,Meazza, Marta,J?rgensen, Karl Anker
supporting information, p. 10661 - 10665 (2018/07/30)
A novel reaction that provides chiral allenes by amino catalytic activation of either aldehydes or α,β-unsaturated aldehydes for reaction with alkynyl-substituted enones is presented. The reaction forms a variety of trisubstituted allenes in high yields a
NOVEL STAT3 PATHWAY INHIBITOR AND CANCER STEM CELL INHIBITOR
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, (2016/10/10)
PROBLEM TO BE SOLVED: To provide novel Stat3 pathway inhibitors, and to provide cancer stem cell inhibitors. SOLUTION: The present invention relates to: a novel naphtho class of compounds as Stat3 pathway inhibitors and as cancer stem cell inhibitors; met
Cascade palladium-catalyzed direct intramolecular arylation/alkene isomerization sequences: Synthesis of indoles and benzofurans
Yagoubi, Myriam,Cruz, Ana C. F.,Nichols, Paula L.,Elliott, Richard L.,Willis, Michael C.
supporting information; experimental part, p. 7958 - 7962 (2011/01/11)
One route, two cycles: A palladium-catalyzed intramolecular direct arylation reaction combined with an isomerization step provided a straightforward synthetic route to both indoles and benzofurans (see scheme). Isolation and functionalization of intermedi
THE AdNSNE MECHANISM IN THE REACTION OF PHENOL AND BENZENETHIOL WITH α-BROMO MICHAEL ACCEPTORS IN THE K2CO3-ACETONE SYSTEM
Rosnati, Vittorio,Saba, Antonio,Salimbeni, Aldo,Vettori, Umberto
, p. 249 - 256 (2007/10/02)
In the reaction of α-bromo Michael acceptors with either phenol or benzenethiol formal substitution of the vinylic bromine proceeds through addition of the phenolic reagent, followed by nucleophilic substitution and β-elimination (AdNSNE mechanism) in the system K2CO3-acetone.The process is shown to be stereospecific in the case of 2a,b and 3b,c, leading to the corresponding Z isomer.The reactivity of substrates 1-4 is discussed in terms of their structural features.
