65320-75-4

Basic information

• Product Name: Propanamide, N-[1-(2-hydroxyethyl)-4-piperidinyl]-N-phenyl-
• CAS NO: 65320-75-4
• Molecular Formula: C16H24N2O2
• Molecular Weight: 276.379
• Mol File: 65320-75-4.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Propanamide, N-[1-(2-hydroxyethyl)-4-piperidinyl]-N-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Propanamide, N-[1-(2-hydroxyethyl)-4-piperidinyl]-N-phenyl-(65320-75-4)
• EPA Substance Registry System: Propanamide, N-[1-(2-hydroxyethyl)-4-piperidinyl]-N-phenyl-(65320-75-4)

Safety Data

• Hazardous Substances Data: 65320-75-4(Hazardous Substances Data)

Upstream product

• 75-21-8 oxirane 
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Relevant articles and documents

Pharmacological profile of a novel series of NK1, antagonists. In vitro and in vivo potency of benzimidazolone derivatives

By low throughput examination of our chemical library, compound 7 was selected as a lead NK1, antagonist with a K(i) of 7.1 nM. Modifications of its structure led to the finding that the in vitro potency could be markedly enhanced by disubstituting the anilino phenyl ring as in compounds 13 or 22. Human binding data correlated rather well with results obtained with in vitro animal smooth muscle preparations. Several agents proved to possess antinociceptive properties as exemplified in the hot-plate test in mice; compound 13 was the most active with ED50 of 0.001 and 0.3 mg/kg after iv and po administration respectively. Furthermore, antagonist 71 was found to be a potent inhibitor of SP-induced bronchoconstriction in guinea-pigs with an ED50 between 0.1 and 0.03 mg/kg iv. Furthermore, upon oral administration, 71 was observed to be active in a model of SP-induced bronchial hypersensitivity in mice, with an ID50 of around 3 mg/kg.

Aminopiperidines, their production and the pharmaceutical compositions incorporating them

This invention relates to 4-aminopiperidines and more precisely to 4-aminopiperidines the nitrogen atom of the piperidine ring is substituted with an aryl lower alkyl side-chain. This invention also relates to processes for producing the same. This invention further extends to pharmaceutical compositions and to the method of using the same.