65326-28-5Relevant academic research and scientific papers
1,3-Dipolar cycloaddition reactions of 4-halophenyl-phthalazinium ylides to activated alkenes and alkynes
Caprosu, Maria C.,Zbancioc, Gheorghita N.,Moldoveanu, Costel C.,Mangalagiu, Ionel I.
, p. 426 - 434 (2004)
For the first time in the benzodiazinium ylide series cycloaddition of (4-halophenyl) substituted ylides to activated alkenes and alkynes was studied. The ability of these ylides to react with acrylonitrile, N-phenylmaleimide, ethyl propiolate and dimethyl acetylenedicarboxylate was investigated. The stereochemistry and regiochemistry involved in these reactions are also discussed. Two new salts and ten new azabicyclic compounds have been obtained.
Synthesis, molecular modelling and anticancer evaluation of new pyrrolo[1,2-b]pyridazine and pyrrolo[2,1-a]phthalazine derivatives
Popovici, Lacramioara,Amarandi, Roxana-Maria,Mangalagiu, Ionel I.,Mangalagiu, Violeta,Danac, Ramona
, p. 230 - 243 (2019/01/10)
Two new series of heterocyclic derivatives with potential anticancer activity, in which a pyrrolo[1,2-b]pyridazine or a pyrrolo[2,1-a]phthalazine moiety was introduced in place of the 3′-hydroxy-4′-methoxyphenyl ring of phenstatin have been synthesised and their structure-activity relationship (SAR) was studied. Fourteen of the new compounds were evaluated for their in vitro cytotoxic activity by National Cancer Institute (NCI) against 60 human tumour cell lines panel. The best five compounds in terms of in vitro growth inhibition were screened in the second stage five dose-response studies, three of them showing a very good antiproliferative activity with GI50100 nM on several cell lines including colon, ovarian, renal, prostate, brain and breast cancer, melanoma and leukemia. Docking experiments on the biologically active compounds showed a good compatibility with the colchicine binding site of tubulin.
Microwave assisted 1,3-dipolar cycloaddition reactions of 2-(4-halobenzoyl) phthalazinium methylides
Zbancioc, Gheorghi?ǎ N.,Caprosu, Maria C.,Moldoveanu, Costel C.,Petrovanu, Magda,Mangalagiu, Ionel I.
, p. 353 - 358 (2007/10/03)
The cycloaddition reactions, in liquid and solid phase, of 2-(4-halobenzoyl) phthalazinium methylides to activated alkenes and alkynes by classical heating and under microwaves were studied. The microwave assisted reaction of phthalazinium ylides to activ
