65331-00-2Relevant academic research and scientific papers
SUBSTITUTED BUTANOLIDES AND BUTENOLIDES. II. SYNTHESIS OF 3-(2-OXOPROPYL)- AND 3-BUTANOLIDES USING THE REACTION OF 2-BUTENOLIDE WITH CH-ACIDS
Naidenov, Yu. V.,Badovskaya, L. A.,Ignatenko, A. V.
, p. 1070 - 1072 (2007/10/02)
The reaction of 2-butenolide with malonate and acetoacetate esters as well as with acetylacetone in the presence of sodium alcoholates proceeds through a step involving the selective addition of the CH-acid anion at C3 of the lactone ring and is accompanied by ring opening.The γ-hydroxyacids formed in acid medium are converted into 3-substituted butanolides, namely, 3-(2-oxopropyl)- and 3-butanolides which had not been described previously.
