65331-29-5Relevant academic research and scientific papers
An efficient and environmentally friendly procedure for the synthesis of some novel 8-Benzylidene-4-phenyl-3,4,5,6,7,8-hexahydro-1H-quinazolin-2-ones/ thiones using tetrabutylammonium hexatungstate as a reusable heterogeneous catalyst under solvent-free conditions
Ghashang, Majid,Mansoor, Syed Sheik,Aswin, Krishnamoorthy
, p. 3289 - 3294 (2014/01/06)
An efficient method for the preparation of 8-benzylidene-4-phenyl-3,4,5,6, 7,8-hexahydro-1H-quinazolin-2- ones/thiones from the reaction of aromatic aldehydes with cyclohexanone and urea or thiourea in the presence of Tetrabutylammonium hexatungstate, [TBA]2[W6O 19], as an efficient, inexpensive catalyst under thermal and solvent-free conditions has been developed. Good yields, short reaction times, straightforward workup, reusability of the catalyst, and green conditions are the most obvious advantages of this procedure.
An efficient ultrasonic-assisted synthesis of the thiazolo[2,3-b] quinazoline and thiazolo[3,2-a] pyrimidine derivatives
Darehkordi, Ali,Reentan, Jabber,Ramezani, Mahin
, p. 385 - 392 (2013/07/27)
Treatment of cyclohexanone or cyclopentanone (2) with aromatic aldehyde (1) and thiourea (3) in the presence of modified montmorinollite nanostructure or HCl as a catalyst under heating and solvent-free conditions produced 7-benzylidene-4-aryl-3,4,6,7-tetrahydro-1H cyclopenta[d]pyrimidine-2(5H)-thione or 8-benzylidene-4-aryl-3,4,5,6,7,8 hexahydroquinazoline-2(1H)-thione (4). Compound 4 was utilized as a key intermediate for the synthesis of new thiazolo[2,3-b]quinazoline and thiazolo[3,2-a]pyrimidine derivatives (5a-5o) via the reaction with diethyl and dimethyl acetylene dicarboxylate by two different methods: (a) in methanol as a solvent under ultrasonic irradiation at ambient temperature; (b) in methanol as a solvent at ambient temperature (conventional magnetic stirring). Ultrasound-assisted synthesis provides excellent yields (87-95 %) in short reaction times (30-50 min) at room temperature. The chemical structures of the newly synthesized compounds were characterized by UV-Vis, IR and NMR spectral and elemental analysis.
Base-catalysed cyclocondensation of α,α′- bis(arylmethylene)cyclohexanones with thiourea: Formation of E-8-(arylmethylene)-4-aryl-1,2,3,4,5,6,7,8-octahydrobenzo[d]pyrimidine-2-thiones
Pal, Rammohan,Mandai, Tapas K.,Mallik, Asok K.
experimental part, p. 402 - 405 (2010/06/16)
Base-catalysed cyclocondensation of α,α′- bis(arylmethylene)cyclohexanones with thiourea has been found to generate E-8-(arylmethylene)-4-aryl-1,2,3,4,5,6,7,8-octahydrobenzo[d]pyrimidine-2- thiones in high yield, the structures of which have been established from their spectral data. However, corresponding cyclopentanones were found to be unreactive under similar reaction condition.
