65355-32-0

Basic information

• Product Name: trans-4'-Propyl-(1,1'-bicyclohexyl)-4-carboxylic acid
• Synonyms: (TRANS,TRANS)-4'-PROPYL-[1,1'-BICYCLOHEXYL]-4-CARBOXYLIC ACID;4'-PROPYL-BICYCLOHEXYL-4-CARBOXYLIC ACID;Trans-4-n-propyl cyclohexyl-cyclohexane-4"-carboxylic acid;Trans-4-Propyl-(1,1-Bicyclohexyl)-4-CarboxylicAcid,3HhaC16H28O2;4-trans-(4-trans-Propylcyclohexyl)-cyclohexancarbonsure;trans-4-（trans-4’-propylcyclohexyl）cyclohexane carboxylic acid;trans-4'-Propyl-(1,1'-bicyclohexyl)-4-carboxylic acid;3HHA
• CAS NO: 65355-32-0
• Molecular Formula: C₁₆H₂₈O₂
• Molecular Weight: 252.39
• Product Categories: Chiral Reagents;Intermediates & Fine Chemicals;Pharmaceuticals;Liqiud crystal intermediates
• Mol File: 65355-32-0.mol
• Article Data: 3

Chemical Properties

• Melting Point: 200℃
• Boiling Point: 370.9±10.0 °C(Predicted)
• Appearance: /
• Density: 0.998±0.06 g/cm3(Predicted)
• Vapor Pressure: 0Pa at 25℃
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: Chloroform, Methanol (Sparingly)
• PKA: 4.90±0.10(Predicted)
• CAS DataBase Reference: trans-4'-Propyl-(1,1'-bicyclohexyl)-4-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: trans-4'-Propyl-(1,1'-bicyclohexyl)-4-carboxylic acid(65355-32-0)
• EPA Substance Registry System: trans-4'-Propyl-(1,1'-bicyclohexyl)-4-carboxylic acid(65355-32-0)

Safety Data

• Hazardous Substances Data: 65355-32-0(Hazardous Substances Data)

Usage

Chemical Properties

White crytallized powder

Uses

Different sources of media describe the Uses of 65355-32-0 differently. You can refer to the following data:
1. trans-4''-Propyl-(1,1''-bicyclohexyl)-4-carboxylic Acid is used for preparation of bihexyl derivatives.
2. Intermediates of Liquid Crystals
3. trans-4'-Propyl-(1,1'-bicyclohexyl)-4-carboxylic Acid is used for preparation of bihexyl derivatives.

Flammability and Explosibility

Notclassified

Upstream product

• 65355-29-5 4-(trans-4'-propylcyclohexyl)-benzoic acid 
• 65355-35-3 trans,trans-4'-propyl-[1,1'-bicyclohexyl]-4-carbonitrile 

Downstream Products

• 494213-18-2 4-{difluoro[(trans,trans)-4'-propyl(1,1'-bicyclohexyl)-4-yl]methoxy}benzenamine 
• 494213-17-1 1-{difluoro[(trans,trans)-4'-propyl(1,1'-bicyclohexyl)-4-yl]methoxy}-4-nitrobenzene 

Relevant articles and documents

Improved synthesis of trans-4-alkylcyclohexane carboxylic acids

Several stereomerically pure amino acid derivatives containing the N-terminal trans-4-alkylcyclohexanoyl fragment were obtained. Hydrogenation of 4-alkylbenzoic acids in the presence of a special Ru-Ni/C catalytic system and isomerization of the resulting mixture of trans- and cis-isomers of 4-alkylcyclohexanecarboxylic acids were used as the key steps. The stereomeric configuration of all compounds was confirmed by 1H NMR spectroscopy. The compounds obtained possess a broad biological activity potential and are useful intermediates in the synthesis of stereomerically pure modified peptides.

HYDROGENATION OF p-(trans-4-ALKYLCYCLOHEXYL) BENZOIC ACIDS IN ALKALINE CONDITIONS.

In a previous work it was shown that reduction of alkylbenzoic acids by sodium in amyl alcohol gives a higher percentage content of the trans isomer than other methods because of subsequent isomerization of the resultant mixture of cis and trans isomers of alkylcyclohexanecarboxylic acids under the influene of soidum alcoholate. In this work this method was used for reduction of p-(trans-4-alkylcyclohexyl)benzoic acids (II), the liquid-crystal properties of which are conclusive evidence of trans-1,4-diequatorial substitution of the cyclohexane group. Experimental evidence shows that reduction of p-(4-trans-butyclohexyl) benzoic acid (II) with Na/C//5H//1//1OH leads to formation of 4-trans-(4-trans-butylcyclohexyl) cyclohexaneacarboxylic left bracket (I)-trans right bracket and 4-cis-(4-trans-butylcyclohexyl) cyclohexanecarboxylic left bracket (I)-cis right bracket acids; in the course of reduction with NaOC//5H//1//1 the latter of these acids undergoes isomerization to (I)-trans to give an equilibrium mixture consisting of 92% (I)-trans and 8% (I)-cis.