653570-89-9

Upstream product

• 149342-35-8 ethyl 2,3,6-trideoxy-3,6-imino-4,5-O-isopropylidene-D-ribohexonate 
• 653571-04-1 N-(tert-butoxycarbonyl)-(2S,3S,4R)-2-[2-(phenylamino)ethyl]-3,4-O-isopropylidenepyrrolidine-3,4-diol 
• 114364-62-4 ethyl 2,3,6-trideoxy-3,6-imino-4,5-O-isopropylidene-D-ribo-hexanoate 
• 545427-21-2 N-(tert-butoxycarbonyl)-2,3,6-trideoxy-3,6-imino-4,5-O-isopropylidene-D-arabino-2-hexose 
• 62-53-3 aniline 
• 294172-61-5 3,6-[(tert-butoxy)carbonyl]imino-2,3,6-trideoxy-4,5-O-isopropylidene-L-arabino-hexose 
• 388077-02-9 2,2-dimethyl-4-(2-oxo-ethyl)-tetrahydro-[1,3]dioxolo[4,5-c]pyrrole-5-carboxylic acid tert-butyl ester 
• 388077-03-0 N-(tert-butoxycarbonyl)-(2R,3R,4S)-2-[2-(phenylamino)ethyl]-3,4-O-isopropylidenepyrrolidine-3,4-diol 

Relevant academic research and scientific papers

Synthesis and glycosidase inhibitory activities of 2-(aminoalkyl) pyrrolidine-3,4-diol derivatives

Several 2-(aminomethyl)-and 2-(2-aminoethyl)-pyrrolidine-3,4-diol derivatives have been assayed for their inhibitory activities towards glycosidases. Good inhibitors of α-mannosidases must have the (2R,3R,4S) configuration and possess 2-(benzylamino)methy

Derivatives of (2R,3R,4S)-2-aminomethylpyrrolidine-3,4-diol are selective α-mannosidase inhibitors

A collection of (2R,3R,4S)-3,4-dihydroxypyrrolidin-2-yl derivatives have been tested for their inhibitory activities toward 25 glycosidases. Competitive (Ki = 7.4 μM) and selective inhibition of α-mannosidase from jack bean has been found for (