653573-91-2

Upstream product

• 653573-88-7 (2S,2aS,4R,4aR,5R,6R,7R,7aS,7bR)-5-tert-butyldimethylsiloxy-4-[4-methoxy-3-(methoxymethoxy)benzyl]-6,7-(isopropylidenedioxy)decahydroindeno[7,1-bc]furan-2-ol 
• 653573-85-4 (2S,2aS,4S,4aS,5R,6R,7R,7aS,7bR)-5-tert-butyldimethylsilyloxy-2-hydroxy-6,7-(isopropylidenedioxy)decahydroindeno[7,1-bc]furan-4-carbaldehyde 
• 1779-49-3 Methyltriphenylphosphonium bromide 
• 653573-90-1 (1R,3R,3aR,4R,5R,6S,7aR)-4-tert-butyldimethylsiloxy-5,6-isopropylidenedioxy-3-[4-methoxy-3-(methoxymethoxy)benzyl]-7-oxooctahydroinden-1-carbaldehyde 

Downstream Products

• 653573-92-3 (1S,3R,3aR,4R,5R,6R,7aS)-4-tert-butyldimethylsiloxy-3-(3-hydroxy-4-methoxybenzyl)-7-methylene-1-(vinyl)octahydroindene-5,6-diol 
• 653573-96-7 (1S,3R,3aR,4S,7aS)-3-(3-acetoxy-4-methoxybenzyl)-7-methylene-1-vinyl-1,2,3,3a,7,7a-hexahydroinden-4-ol 
• 653573-95-6 (1S,3R,3aR,4S,7aS)-3-(3-acetoxy-4-methoxybenzyl)-4-tert-butyldimethylsiloxy-7-methylene-1-vinyl-1,2,3,3a,7,7a-hexahydroindene 
• 653573-93-4 (1S,3R,3aR,4R,5R,6R,7aS)-3-(3-acetoxy-4-methoxybenzyl)-4-tert-butyldimethylsiloxy-7-methylene-1-(vinyl)octahydroindene-5,6-diol 
• 653573-94-5 (3aR,4R,4aR,5R,7S,7aS,8aR)-5-(3-acetoxy-4-methoxybenzyl)-4-tert-butyldimethylsiloxy-8-methylene-7-(vinyl)octahydroindeno[5,6-d,1,3]dioxol-2-thione 

Relevant academic research and scientific papers

Enantioselective total synthesis of (+)-ottelione A, (-)-ottelione B, (+)-3-epi-ottelione A and preliminary evaluation of their antitumor activity

Enantioselective total synthesis of (+)-ottelione A (1) and (-)ottelione B (2), novel and potent antitumor agents from a freshwater plant, and (+)-3-epi-ottelione A (3), the earlier proposed stereostructure of 1, was efficiently achieved starting from the

Enantioselective Total Synthesis of 3-epi-Ottelione A

An enantioselective total synthesis of (+)-3-epi-ottelione A (2), the earlier proposed stereostructure of the antitumor natural product ottelione A (4), was achieved for the first time starting from the known tetracyclic compound 9. The synthesis involves the following three crucial steps: (i) a coupling reaction of aldehyde 8 and aryllithium 7 to introduce the aromatic portion, (ii) base-induced lactol-opening/epimerization at the C1 position of 6 to deliver the requisite hydrindane 15, and (iii) Corey-Winter's reductive olefination of the cyclic thiocarbonate 19 to install the C5-C6 double bond.