653586-70-0Relevant academic research and scientific papers
Discovery of Topsentin Alkaloids and Their Derivatives as Novel Antiviral and Anti-phytopathogenic Fungus Agents
Ji, Xiaofei,Wang, Ziwen,Dong, Ji,Liu, Yuxiu,Lu, Aidang,Wang, Qingmin
, p. 9143 - 9151 (2016/12/16)
Topsentin alkaloids and their derivatives were designed, synthesized, and characterized on the basis of NMR and mass spectroscopy. The antiviral activities against tobacco mosaic virus (TMV) and anti-phytopathogenic fungus activities of these alkaloids were evaluated for the first time. Alkaloids 1c, 1e, 2b, and 2d displayed significantly higher antiviral activities against TMV than Ribavirin, emerging as new lead compounds for anti-TMV research. Further fungicidal activity tests against 14 kinds of phytopathogenic fungi revealed that these alkaloids displayed broad-spectrum fungicidal activities. Topsentin derivative 2d with 4-5 mg/kg EC50 values against Sclerotinia sclerotiorum (Lib.), Rhizoctonia solani (Kuhn), and Botrytis cinerea (Pers.) emerged as a new lead compound for fungicidal research. Current studies provide support for the application of topsentin alkaloids as novel agrochemicals.
An efficient and practical synthesis of aryl and hetaryl α-keto esters
Raghunadh, Akula,Meruva, Suresh Babu,Kumar, Nuka Anil,Kumar, Gudla Santosh,Rao, L. Vaikunta,Syamkumar
supporting information; experimental part, p. 283 - 289 (2012/03/26)
A general and highly efficient method was developed for the synthesis of -keto esters by oxidative esterification of 2,2-dibromo-1-(het)arylethanones by sequential treatment with dimethyl sulfoxide and an alkanol. The versatility of the reaction was established by synthesizing a range of -keto esters by treatment of 2,2-dibromoethanones, derived from aryl or hetaryl ketones, with di-methyl sulfoxide and a cyclic or acyclic primary or secondary alcohol. The mechanism of the reaction was established by means of a detailed study. Georg Thieme Verlag Stuttgart · New York.
A total synthesis of (±)-α-cyclopiazonic acid using a cationic cascade as a key step
Griffiths-Jones, Charlotte M.,Knight, David W.
experimental part, p. 8515 - 8528 (2011/11/29)
The indole alkaloid α-cyclopiazonic acid 1 has been synthesised by a route, which features at its core an acid-catalysed cationic cascade cyclisation terminated by a sulfonamide group.
