653604-33-2

Basic information

• Product Name: Carbamic acid, [[4-[[(6-cyano-2-naphthalenyl)carbonyl]amino]phenyl]methyl]-, 1,1-dimethylethyl ester
• CAS NO: 653604-33-2
• Molecular Formula: C24H23N3O3
• Molecular Weight: 401.465
• Mol File: 653604-33-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Carbamic acid, [[4-[[(6-cyano-2-naphthalenyl)carbonyl]amino]phenyl]methyl]-, 1,1-dimethylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamic acid, [[4-[[(6-cyano-2-naphthalenyl)carbonyl]amino]phenyl]methyl]-, 1,1-dimethylethyl ester(653604-33-2)
• EPA Substance Registry System: Carbamic acid, [[4-[[(6-cyano-2-naphthalenyl)carbonyl]amino]phenyl]methyl]-, 1,1-dimethylethyl ester(653604-33-2)

Safety Data

• Hazardous Substances Data: 653604-33-2(Hazardous Substances Data)

Upstream product

• 69008-41-9 6-(Chlorocarbonyl)-2-naphthalenecarboxylic acid,methyl ester 
• 4403-71-8 (4-aminomethyl)aniline 
• 5088-91-5 6-cyano-naphthalene-2-carboxylic acid methyl ester 
• 7568-08-3 naphthalene-2,6-dicarboxylic acid monomethyl ester 
• 5159-60-4 6-cyano-naphthalene-2-carboxylic acid 
• 94838-55-8 tert-butyl (4-aminobenzyl)carbamate 

Downstream Products

• 1360630-70-1 C₂₄H₂₅N₃O₃S 

Relevant articles and documents

Synthesis and evaluation of non-basic inhibitors of urokinase-type plasminogen activator (uPA)

Recent drug discovery programs targeting urokinase plasminogen activator (uPA) have resulted in nonpeptidic inhibitors consisting of amidine or guanidine functional groups attached to aromatic or heteroaromatic scaffolds. There is a general problem of poor oral bioavailability of these charged inhibitors. In this paper, we report the synthesis and evaluation of a series of naphthamide and naphthalene sulfonamides as uPA inhibitors containing non-basic groups as substitute for amidine or guanidine groups.