65367-85-3 Usage
Uses
Used in Anticancer Applications:
5-(PROPARGYLOXY)-2'-DEOXYURIDINE is used as a therapeutic agent for the potentiation of antitumor activity. It enhances the effectiveness of 5-fluorouracil, a widely used chemotherapeutic drug, when combined with interferon. This combination therapy has shown potential in improving the treatment outcomes for various types of cancer.
Used in Biological Research:
5-(PROPARGYLOXY)-2'-DEOXYURIDINE is also used as a research tool in the study of deoxyuridine derivatives and their biological activities. Its unique chemical structure allows researchers to investigate the mechanisms of action and potential applications of this class of compounds in various biological processes and disease states.
Check Digit Verification of cas no
The CAS Registry Mumber 65367-85-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,5,3,6 and 7 respectively; the second part has 2 digits, 8 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 65367-85:
(7*6)+(6*5)+(5*3)+(4*6)+(3*7)+(2*8)+(1*5)=153
153 % 10 = 3
So 65367-85-3 is a valid CAS Registry Number.
InChI:InChI=1/C12H14N2O6/c1-2-3-19-8-5-14(12(18)13-11(8)17)10-4-7(16)9(6-15)20-10/h1,5,7,9-10,15-16H,3-4,6H2,(H,13,17,18)
65367-85-3Relevant academic research and scientific papers
5-O-alkylated derivatives of 5-hydroxy-2'-deoxyuridine as potential antiviral agents. Anti-herpes activity of 5-propynyloxy-2'-deoxyuridine
Torrence,Spencer,Bobst
, p. 228 - 231 (2007/10/09)
Alkylation of 5-hydroxyuridine or 5-hydroxy-2'-deoxyuridine with various activated alkylating agents in the presence of 1 equiv of NaOH gave a series of new nucleoside analogues which were evaluated for antiviral activity against vaccinia virus, herpes simplex-1 virus, and vesicular stomatitis virus in both primary rabbit kidney cells and human skin fibroblasts. One of these analogues, 5-propynyloxy-2'-deoxyuridine, was a potent inhibitor of herpes simplex virus. Structure-activity considerations suggest that the anti-herpes activity is dependent on the integrity of the acetylene group since substitution of phenyl, p-nitrophenyl, vinyl, carboxamido, or carboxyl for the triple bond led to diminished antiviral activity.
