65367-99-9 Usage
Uses
Used in Pharmaceutical Drug Development:
4-(3-Chlorophenoxy)piperidine hydrochloride is used as a key intermediate in the synthesis of various pharmaceutical drugs. Its unique structure allows for the development of new drug candidates with potential therapeutic effects on a range of health conditions.
Used in Organic Synthesis:
4-(3-CHLOROPHENOXY)PIPERIDINE HYDROCHLORIDE serves as a valuable building block in organic synthesis, enabling the creation of a variety of complex organic molecules with diverse applications.
Used in Enzyme Inhibition:
4-(3-Chlorophenoxy)piperidine hydrochloride has demonstrated potential as an inhibitor of the enzyme arylamine N-acetyltransferase, which plays a crucial role in drug metabolism and detoxification. By inhibiting this enzyme, it may help modulate the activity of certain drugs and improve their therapeutic effects.
Used in Neurological and Psychiatric Disorders:
Research has shown that 4-(3-Chlorophenoxy)piperidine hydrochloride may have potential therapeutic effects on various neurological and psychiatric disorders. Its precise mechanism of action and the extent of its efficacy in these conditions are still under investigation.
Check Digit Verification of cas no
The CAS Registry Mumber 65367-99-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,5,3,6 and 7 respectively; the second part has 2 digits, 9 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 65367-99:
(7*6)+(6*5)+(5*3)+(4*6)+(3*7)+(2*9)+(1*9)=159
159 % 10 = 9
So 65367-99-9 is a valid CAS Registry Number.
65367-99-9Relevant academic research and scientific papers
NOVEL PIPERAZINE DERIVATIVES AS INHIBITORS OF STEAROYL-CoA DESATURASE
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Page/Page column 64, (2009/10/01)
The present invention relates to piperidine derivatives that act as inhibitors of stearoyl-CoA desaturase. The invention also relates to methods of preparing the compounds, compositions containing the compounds, and to methods of treatment using the compounds.
Discovery of piperidine-aryl urea-based stearoyl-CoA desaturase 1 inhibitors
Xin, Zhili,Zhao, Hongyu,Serby, Michael D.,Liu, Bo,Liu, Mei,Szczepankiewicz, Bruce G.,Nelson, Lissa T.J.,Smith, Harriet T.,Suhar, Tom S.,Janis, Rich S.,Cao, Ning,Camp, Heidi S.,Collins, Christine A.,Sham, Hing L.,Surowy, Teresa K.,Liu, Gang
supporting information; scheme or table, p. 4298 - 4302 (2009/04/06)
A series of structurally novel stearoyl-CoA desaturase1 (SCD1) inhibitors has been identified via molecular scaffold manipulation. Preliminary structure-activity relationship (SAR) studies led to the discovery of potent, and orally bioavailable piperidine-aryl urea-based SCD1 inhibitors. 4-(2-Chlorophenoxy)-N-[3-(methyl carbamoyl)phenyl]piperidine-1-carboxamide 4c exhibited robust in vivo activity with dose-dependent desaturation index lowering effects.
