65369-27-9

Upstream product

• 66319-05-9 2-<(2-Methoxycarbonyl)ethylthio>propionsaeure-ethylester 

Downstream Products

• 78648-42-7 4-Hydroximino-2-methyl-4-oxo-tetrahydrothiophen-3-carbonsaeuremethylester 
• 84782-96-7 3-Benzyl-2-methyl-4-oxo-tetrahydro-thiophene-3-carboxylic acid methyl ester 
• 94562-42-2 2-Methyl-3-(4-nitro-benzyl)-4-oxo-tetrahydro-thiophene-3-carboxylic acid methyl ester 
• 227312-08-5 2-methyl-4-((4-methylphenyl)sulfonyl)oxy-3-thiophenecarboxylic acid methyl ester 
• 227312-13-2 2-methyl-5-nitro-4-(phenylmethyl)thio-3-thiophenecarboxylic acid methyl ester 
• 227312-10-9 2-methyl-4-((4-methylphenyl)sulfonyl)oxy-5-nitro-3-thiophenecarboxylic acid methyl ester 
• 1429638-99-2 1-cyclopropyl-3-(4(R)-(5-methyl-4-((S)-3-methylmorpholino)-6,6-dioxido-5,7-dihydrothieno[3,4-d]pyrimidin-2-yl)phenyl)urea 
• 1429639-00-8 1-cyclopropyl-3-(4(S)-(5-methyl-4-((S)-3-methylmorpholino)-6,6-dioxido-5,7-dihydrothieno[3,4-d]pyrimidin-2-yl)phenyl)urea 
• 227312-15-4 5-amino-2-methyl-4-(phenylmethyl)thio-3-thiophenecarboxylic acid methyl ester 
• 227312-03-0 2,5-dihydro-2-methyl-4-((4-methylphenyl)sulfonyl)oxy-3-thiophenecarboxylic acid methyl ester 
• 65369-28-0 methyl 4-hydroxy-2-methylthiophene-3-carboxylate 
• 1001124-14-6 tert-butyl (R)-3-(4-chloro-3-fluorophenyl)-1-((S)-3-methyl-4-((S)-5-methyl-5,7-dihydrothieno[3,4-d]pyrimidin-4-yl)piperazin-1-yl)-1-oxopropan-2-ylcarbamate 
• 1001124-18-0 tert-butyl (R)-3-(3,4-difluorophenyl)-1-((S)-3-methyl-4-((S)-5-methyl-5,7-dihydrothieno[3,4-d]pyrimidin-4-yl)piperazin-1-yl)-1-oxopropan-2-ylcarbamate 
• 1001124-48-6 tert-butyl (R)-3-(4-chloro-3-fluorophenyl)-1-(4-((R)-5-methyl-5,7-dihydrothieno[3,4-d]pyrimidin-4-yl)piperazin-1-yl)-1-oxopropan-2-ylcarbamate 

Relevant academic research and scientific papers

MORPHOLINO SUBSTITUTED BICYCLIC PYRIMIDINE UREA OR CARBAMATE DERIVATIVES AS MTOR INHIBITORS

The invention relates to compounds of formula (I) wherein m, o, Ra, Rb, R1 and T1 have the meaning as cited in the description and the claims. Said compounds are useful as inhibitors of mTOR for the treatment or prophylaxis of mTOR related diseases and disorders. The invention also relates to pharmaceutical compositions including said compounds, the preparation of such compounds as well as the use as medicaments