65373-43-5

Basic information

• Product Name: 1-(2,4-dimethoxyphenyl)-3-(pyridin-4-yl)propan-1-ol
• Synonyms: 1-(2,4-dimethoxyphenyl)-3-(pyridin-4-yl)propan-1-ol
• CAS NO: 65373-43-5
• Molecular Weight: 273.332
• Mol File: 65373-43-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-(2,4-dimethoxyphenyl)-3-(pyridin-4-yl)propan-1-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2,4-dimethoxyphenyl)-3-(pyridin-4-yl)propan-1-ol(65373-43-5)
• EPA Substance Registry System: 1-(2,4-dimethoxyphenyl)-3-(pyridin-4-yl)propan-1-ol(65373-43-5)

Safety Data

• Hazardous Substances Data: 65373-43-5(Hazardous Substances Data)

Upstream product

• 100-43-6 4-vinylpyridine 
• 613-45-6 2,4-Dimethoxybenzaldehyde 

Relevant articles and documents

β-Selective Reductive Coupling of Alkenylpyridines with Aldehydes and Imines via Synergistic Lewis Acid/Photoredox Catalysis

Umpolung (polarity reversal) strategies of aldehydes and imines have dramatically expanded the scope of carbonyl and iminyl chemistry by facilitating reactions with non-nucleophilic reagents. Herein, we report the first visible light photoredox-catalyzed β-selective reductive coupling of alkenylpyridines with carbonyl or iminyl derivatives with the aid of a Lewis acid co-catalyst. Our process tolerates complex molecular scaffolds (e.g., sugar, natural product, and peptide derivatives) and is applicable to the preparation of compounds containing a broad range of heterocyclic moieties. Mechanistic investigations indicate that the key step involves single-electron-transfer reduction of aldehydes or imines followed by the addition of resulting ketyl or α-aminoalkyl radicals to Lewis acid-activated alkenylpyridines.