65383-33-7Relevant academic research and scientific papers
An expeditious synthetic protocol for chlorination of imidazole N-oxide: Synthesis of 2-chloroimidazoles
Hossain, Mossaraf,Pradhan, Kiran,Nanda, Ashis Kumar
supporting information, p. 3772 - 3776 (2017/09/09)
An expeditious, one-pot and room temperature protocol is reported for the synthesis of 2-chloroimidazoles from imidazole N-oxide. Simple mixing of the imidazole N-oxide, derived easily from diacetyl monoxime via three-component reaction, with oxalyl chlor
Synthesis of 2-unsubstituted 1-arylimidazoles
Mityanov,Perevalov,Tkach
, p. 1793 - 1800 (2013/07/26)
A method has been developed for the synthesis of 1-arylimidazoles lacking a substituent at position 2, featuring the preparation of 1-arylimidazole N-oxides stabilized as boron trifluoride derivatives, with subsequent reduction to the desired imidazoles. This method permits broad variation of the substituents in the aryl part of these molecules.
Novel antiprotozoal products: imidazole and benzimidazole N-oxide derivatives and related compounds.
Aguirre, Gabriela,Boiani, Mariana,Cerecetto, Hugo,Gerpe, Alejandra,Gonzalez, Mercedes,Sainz, Yolanda Fernandez,Denicola, Ana,De Ocariz, Carmen Ochoa,Nogal, Juan Jose,Montero, David,Escario, Jose Antonio
, p. 259 - 270 (2007/10/03)
The syntheses and biological evaluation of the first anti-protozoa imidazole N-oxide and benzimidazole N-oxide and their derivatives are reported. They were tested in vitro against two different protozoa, Trypanosoma cruzi and Trichomonas vaginalis. Deriv
New synthetic approach for the preparation of imidazole N3-oxide
Cerecetto, Hugo,Gerpe, Alejandra,Gonzalez, Mercedes,Fernandez Sainz, Yolanda,Piro, Oscar E.,Castellano, Eduardo E.
, p. 2678 - 2684 (2007/10/03)
A new synthetic procedure of 1-alkyl(aryl)-1H-4-methylimidazole N 3-oxide derivatives by cyclocondensation of α-amineoximes and orthoesters was studied. Low yields in the cyclization process were the result of predominant Z-stereoisomer around the oxime moiety of α-amineoxime reactants. Different attempts to improve these yields were assayed, mild conditions being those that produce the best results. Also, the special acidity of hydrogen-2 in the imidazole N3-oxide system was studied in solution by NMR spectroscopy. This property provides a convenient intermediate to access 2-substituted analogues.
