654-87-5

Basic information

• Product Name: 2,3,5-TRIFLUOROBENZOIC ACID
• Synonyms: 2,3,5-TRIFLUOROBENZOIC ACID;RARECHEM AL BO 0710;2,3,5-Trilfuorobenzoic acid;2,3,5-Trifluorobenzoic acid 98%;2,3,5-Trifluorobenzoicacid98%;2,3,5-Trilfluorobenzoic acid
• CAS NO: 654-87-5
• Molecular Formula: C₇H₃F₃O₂
• Molecular Weight: 176.09
• Product Categories: Miscellaneous
• Mol File: 654-87-5.mol
• Article Data: 4

Chemical Properties

• Melting Point: 109 °C
• Boiling Point: 240℃
• Flash Point: 99℃
• Appearance: /
• Density: 1.536
• Vapor Pressure: 0.0217mmHg at 25°C
• Refractive Index: 1.49
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: soluble in Methanol
• PKA: 2.59±0.10(Predicted)
• CAS DataBase Reference: 2,3,5-TRIFLUOROBENZOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3,5-TRIFLUOROBENZOIC ACID(654-87-5)
• EPA Substance Registry System: 2,3,5-TRIFLUOROBENZOIC ACID(654-87-5)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 36/37/38-22
• Safety Statements: 26-36
• HazardClass: IRRITANT
• Hazardous Substances Data: 654-87-5(Hazardous Substances Data)

Usage

General Description

2,3,5-Trifluorobenzoic acid is a fluorinated derivative of benzoic acid, specifically with three fluorine atoms attached to the benzene ring at the 2, 3, and 5 positions. It is a white, crystalline solid that is soluble in organic solvents and slightly soluble in water. 2,3,5-TRIFLUOROBENZOIC ACID is commonly used as an intermediate in the synthesis of pharmaceuticals, agrochemicals, and dyes, and as a building block for the production of various fluoroaromatic compounds. It is also utilized as a reagent in organic synthesis reactions, particularly in the preparation of aromatic carboxylic acids and other organic compounds. Additionally, 2,3,5-trifluorobenzoic acid is known to exhibit insecticidal and herbicidal properties, making it useful for the development of crop protection products.

InChI:InChI=1/C7H3F3O2/c8-3-1-4(7(11)12)6(10)5(9)2-3/h1-2H,(H,11,12)

Upstream product

• 1201-31-6 2,3,4,5-tetrafluorobenzoic acid 
• 652-03-9 3,4,5,6-tetrafluorophthalic acid 
• 392-91-6 1,2,5-trifluoro-3-(trifluoromethyl)benzene 

Downstream Products

• 67640-33-9 2,3,5-trifluorobenzyl alcohol 
• 240800-48-0 2,3,5-trifluorobenzoyl chloride 
• 84376-20-5 3,5-difluoro-2-hydroxy-benzoic acid 

Relevant articles and documents

2, 3, 5-trifluoro-4-difluoro (3, 4, 5-trifluoro-density) methyl-benzene formaldehyde and its synthetic method and in the preparation of the application of the liquid crystal compound

The invention provides 2,3,5-trifluoro-4-difluoro(3,4,5-trifluorophenylol)methyl-benzaldehyde (a compound of formula 8), and its preparation method. The compound can be used to synthesize a compound with the structure represented by formula I as an interm

Reductive dehalogenation of polyfluoroarenes by zinc in aqueous ammonia

Aqueous ammonia has been found to be a good and versatile medium for the highly selective hydrodehalogenation of polyfluoroarenes by zinc under unprecedentedly mild conditions. The reduction of pentafluorobenzoic acid, 2,3,4,5,6-pentafluorobenzyl alcohol, pentafluorobenzamide, pentafluoropyridine, heptafluoro-2-naphthoic acid, 1,3,4,5,7,8-hexafluoro-2-naphthoic acid, octafluoronaphthalene, octafluorotoluene, decafluorobiphenyl, chloropentafluorobenzene and 4-chlorotetrafluorobenzoic acid give products derived from the removal of one or two halogen atoms. A reduction mechanism, proceeding through electron capture to give a radical anion and then fragmentation of the latter, has been suggested. The observed high selectivity of the process suggests a radical anion formed by direct electron transfer from zinc to substrate. The dehalogenation regioselectivity is basically in accordance with that expected for radical anion fragmentation.