65400-16-0

Upstream product

• 873-67-6 benzonitrile oxide 
• 542-92-7 cyclopenta-1,3-diene 
• 62-53-3 aniline 
• 698-16-8 benzohydroximoyl chloride 

Downstream Products

• 67672-12-2 3,5-diphenyl-4,4a,7a,7b-tetrahydro-3aH-cyclopenta[1,2-d;4,3-d']diisoxazole 
• 95982-53-9 5ξ,6ξ-dibromo-3-phenyl-(3ar,6ac)-4,5,6,6a-tetrahydro-3aH-cyclopenta[d]isoxazole 
• 42443-85-6 3,6,8a-triphenyl-(3ar,3bt,8ac,8bt,9ac)-3a,3b,8a,8b,9,9a-hexahydro-isoxazolo[4'',5'':3',4']cyclopenta[1',2':4,5]isoxazolo[2,3-d][1,2,4]oxadiazole 
• 42443-84-5 3,8,9b-triphenyl-(5ar,5bt,8at,9ac,9bt)-5a,5b,8a,9,9a,9b-hexahydro-isoxazolo[5'',4'':3',4']cyclopenta[1',2':4,5]isoxazolo[2,3-d][1,2,4]oxadiazole 

Relevant academic research and scientific papers

Copper-Catalyzed Oxidative Oxyamination/Diamination of Internal Alkenes of Unsaturated Oximes with Simple Amines

A convenient and versatile oxidative intra/intermolecular oxyamination and diamination of unactivated alkenes has been developed through copper-catalyzed radical reactions of β,γ- and γ,δ-unsaturated ketoximes with electron-rich aryl and aliphatic amines. These reactions were carried out by employing di-tert-butyl peroxide (DTBP) or air as the terminal oxidant, and a series of useful nitrogen-containing 4,5-dihydroisoxazoles and cyclic nitrones were formed.

Cycloadditions of nitrile oxides to the highly reactive N-acyl-2-oxa-3- azanorborn-5-enes afford versatile cycloadducts and a convenient entry to highly functionalized derivatives

N-Acyl-2-oxa-3-azanorborn-5-enes are highly reactive dipolarophiles in cycloadditions with nitrile oxides. The cycloadducts can be easily elaborated to various functionalized structures that are not directly accessible by 1,3- dipolar cycloadditions.

The mild oxidation of nitrile oxides affords a convenient entry to nitrosocarbonyl intermediates, versatile tools in organic syntheses

Nitrile oxides are oxidized by tertiary amine N-oxides in different solvents at room temperature to afford in the presence of dienes nitrosocarbonyl adducts in fair yields. The mild conditions used in oxidizing a variety of nitrile oxides promise a wide application of this method in synthetic processes.