654061-24-2

Upstream product

• 654061-21-9 (3R,7aS)-6-(2-methylallyl)-3-phenyl-1,7a-dihydropyrrolo[1,2-c]oxazol-5-one 
• 654061-22-0 (1R,4R,4aR,5aR)-5a-(2-methylallyl)-4-phenyltetrahydro-1,3-dioxa-4a-azacyclopropa[a]pentalen-5-one 

Downstream Products

• 654061-26-4 (3aR,6aS,6R)-(5-benzyl-2,2-dimethylhexahydrofuro[2,3-c]pyrrol-6-yl)methanol 
• 654061-25-3 (1R,3aR,3bS,6aR)-5-iodomethyl-5-methyl-1-phenylhexahydro-2,4-dioxa-7a-azacyclopenta[a]pentalen-7-one 

Relevant academic research and scientific papers

Preparation of (2,2-Dimethylhexahydrofuro[2,3-c]pyrrol-6-yl)methanol: A Conformationally Restricted Congener of Nonproteinogenic 3-Hydroxy-4- methylproline

Lactam 6 derived from (S)-pyroglutaminol was converted to a conformationally restricted congener of nonproteinogenic 3-hydroxy-4- methylproline. Preparation of precursor Sb was achieved via a diastereoselective epoxidation followed by a regioselective opening of the oxirane ring. Iodine-mediated cyclization was used to assemble the ether moiety of 2.