65409-11-2

Upstream product

• 153619-54-6 (5S,6R,7R,8S)-6-<8-acetoxy-7,8-dihydro-7-(methoxymethoxy)styryl>-5-(methoxymethoxy)-5,6-dihydro-2H-pyran-2-one 
• 65408-91-5 goniothalenol 
• 108-24-7 acetic anhydride 
• 114488-17-4 (-) Altholactone 
• 114340-93-1 (3aR,3bS,7aR,8aR)-2,2-dimethyl-3a,3b,7a,8a-tetrahydro-5H-[1,3]dioxolo[4',5':4,5]furo[3,2-b]pyran-5-one 
• 124040-09-1 (S)-3-Hydroxy-3-((3aR,5R,6S,6aR)-6-hydroxy-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-5-yl)-propionic acid 
• 114340-92-0 Acetic acid (3aR,3bS,7S,7aR,8aR)-2,2-dimethyl-5-oxo-hexahydro-[1,3]dioxolo[4,5]furo[3,2-b]pyran-7-yl ester 
• 114340-90-8 (S)-3-((3aR,5R,6S,6aR)-6-Benzyloxy-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-5-yl)-3-hydroxy-propionic acid 
• 114340-89-5 (S)-3-((3aR,5R,6S,6aR)-6-Benzyloxy-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-5-yl)-3-hydroxy-propionic acid ethyl ester 
• 908142-25-6 1-2 O-isopropylidene 3-O-benzyl α(D)gluco-pentoaldofuranose 
• 71-43-2 benzene 
• 23558-05-6 3-O-benzyl-1,2-O-isopropylidene-1,5-D-xylo-dialdofuranose 
• 124040-10-4 Benzoic acid (3aR,5R,6S,6aR)-5-((Z)-2-methoxycarbonyl-vinyl)-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-6-yl ester 
• 124061-89-8 3-O-benzoyl-1,2-isopropylidene-α-D-xylo-pentodialdo-1,4-furanose 

Downstream Products

• 65408-91-5 goniothalenol 
• 242150-07-8 Acetic acid (2R,3R,3aR,6S,7R,7aS)-6,7-dihydroxy-5-oxo-2-phenyl-hexahydro-furo[3,2-b]pyran-3-yl ester 

Relevant academic research and scientific papers

(+)-Altholactone exhibits broad spectrum immune modulating activity by inhibiting the activation of pro-inflammatory cytokines in RAW 264.7 cell lines

An evaluation of Indonesian plants to identify compounds with immune modulating activity revealed that the methanolic extract of an Alphonsea javanica Scheff specimen possessed selective anti-inflammatory activity in a nuclear factor-kappa B (NF-κB) lucif

3-Acetylaltholactone and related styryl-lactones, mitochondrial respiratory chain inhibitors

A novel furano-pyrone, 3-acetylaltholactone, and two other known styryl- lactones, altholactone and 5-acetoxyisogoniothalamin oxide, have been isolated from Goniothalamus arvensis (Annonaceae) stem bark. We report here the isolation and structural elucida

Halogenated benzoate derivatives of altholactone with improved anti-fungal activity

Abstract: Altholactone exhibited the anti-fungal activity with a high MIC value of 128?μg?ml?1against Cryptococcus neoformans and Saccharomyces cerevisiae. Fifteen ester derivatives of altholactone 1–15 were modified by esterification and their

Semisynthesis and cytotoxicity of styryl-lactone derivatives

The cytotoxicity and the cell-cycle action of altholactone (1), goniofufurone (2), and eight altholactone derivatives (5-12), were determined in vitro on L-1210 cells. Semisyntheses and structure-activity relationships of these compounds are described. The results of this study suggest that the cytotoxicity of altholactone (1), 11-nitro-altholactone (8), and 7-chloro- 6,7-dihydroaltholactone (10) is due to the accumulation of the cells in the G2 + M phase of the cell cycle.

Stereocontrolled syntheses of novel styryl lactones, (+)-goniodiol, (+)- goniotriol, (+)-8-acetylgoniotriol, (+)-goniofufurone, (+)-9- deoxygoniopypyrone, (+)-goniopypyrone, and (+)-altholactone from common intermediates and cytotoxicity of their congener

Concise syntheses of (+)-goniodiol, (+)-goniotriol, (+)-8- acetylgoniotriol, (+)-goniofufurone, (+)-9-deoxygoniopypyrone, (+)- goniopypyrone, and (+)-altholactone and their congeners from chiral lactonic aldehydes 27 and 36 as common intermediates are des