6541-63-5Relevant academic research and scientific papers
Spirodihydantoin is a minor product of 5-hydroxyisourate in urate oxidation
Yu, Hongbin,Niles, Jacquin C.,Wishnok, John S.,Tannenbaum, Steven R.
, p. 3417 - 3420 (2004)
(Chemical Equation Presented) Spirodihydantoin is a minor product from oxidation of uric acid (～0.15% yield), while spiroiminodihydantoin is a major product from oxidation of 8-oxo-7,8-dihydroguanine (37% yield, pH 10.2). High pH and temperature favor the formation of both spiro compounds. 18O labeling experiments and in situ generation and decomposition of 5-hydroxy-N7-methylisouric acid indicate that spirodihydantoin and allantoin and spiroiminodihydantoin and guanidinohydantoin are products of 5-hydroxyisourate and 5-hydroxy-8-oxo-7,8-dihydroguanine intermediates, respectively.
