65416-85-5Relevant articles and documents
Microwave-assisted synthesis of 2-aminothiophene derivatives via improved gewald reactions
Ruan, Bankang,Zhang, Zhiyan,Huang, Lei,Xu, Chao,Li, Luolan
, p. 2007 - 2018 (2021/09/29)
In this paper, a new and efficient method was developed to prepare 2-aminothiophene derivatives through improved Gewald reaction. Thirty-one final products were synthesized under microwave radiation for 30 min with 57%-95% isolated yields. All the product
MODIFIED PROTEINS AND PROTEIN DEGRADERS
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Paragraph 00924-00926, (2021/12/08)
Provided herein are compounds, pharmaceutical compositions, and methods for binding or degrading target proteins. Further provided herein are compounds having a DNA damage-binding protein 1 (DDB1) binding moiety. Some such embodiments include a linker. Some such embodiments include a target protein binding moiety. Further provided herein are ligand-DDB1 complexes. Further provided herein are in vivo modified DDB1 proteins.
Convenient synthesis of 2-aminothiophene derivatives by acceleration of gewald reaction under ultrasonic aqueous conditions
Mojtahedi, Mohammad M.,Abaee, M. Saeed,Mahmoodi, Peyman,Adib, Mehdi
experimental part, p. 2067 - 2074 (2010/08/13)
Under ultrasound irradiation and in the presence of H2O/Et 2NH, ethyl cyanoacetate or malononitrile can combine with-methylene carbonyl compounds and elemental sulfur to efficiently yield 2-aminothiophene derivatives within a few minutes. Products are easily obtained by simple filtration because of their spontaneous precipitation in the reaction mixtures. Copyright Taylor & Francis Group, LLC.
Herbicidal Thienylureas, II
Stanetty, Peter,Puschautz, Erhard
, p. 65 - 72 (2007/10/02)
In search of novel biological active thiophene derivatives we recently focused our interest on thienylureas.The present paper deals with substances being in close relation to second generation urea herbicides (C).The main part describes syntheses leading to thiophene carboxylic acids with corresponding substitution patterns.A modified Curtius degradation was used as key step for the formation of the thienylureas. - Keywords: Curtius degradation; Herbicides; Thiophenes; Ureas
