65435-05-4

Upstream product

• 59-48-3 2-oxoindole 
• 7148-74-5 2-Bromopropionyl chloride 

Downstream Products

• 128231-21-0 5-(3,6-dihydro-6-methyl-2-oxo-1,3,4-thiadiazin-5-yl)-2,3-dione 3-(pentafluorophenylhydrazone) 
• 128231-41-4 5-(3,6-dihydro-6-methyl-2-oxo-1,3,4-thiadiazin-5-yl)-1H-indol-2,3-dione 3-<4-trifluoromethylphenylhydrazone> 
• 128231-23-2 4-<2-<5-(3,6-dihydro-6-methyl-2-oxo-1,3,4-thiadiazin-5-yl)-2,3-dihydro-2-oxo-1H-indol-3-ylidene>hydrazino>benzoic acid 
• 128231-10-7 5-(3,6-dihydro-6-methyl-2-oxo-2H-1,3,4-thiadiazin-5-yl)-1H-indole-2,3-dione 3<(4-methyl)phenylhydrazone> 
• 128231-11-8 5-(3,6-dihydro-6-methyl-2-oxo-1,3,4-thiadiazin-5-yl)-2,3-dione 3-<(phenylmethyl)hydrazone> 
• 128231-14-1 5-(3,6-dihydro-6-methyl-2-oxo-1,3,4-thiadiazin-5-yl)-2,3-dione 3-(cyclohexylhydrazone) 
• 128231-02-7 1,3-dihydro-5-(3,6-dihydro-6-methyl-2-oxo-2H-1,3,4-thiadiazin-5-yl)-3-phenoxyimino-2H-indol-2-one 
• 128230-97-7 5-(3,6-dihydro-6-methyl-2-oxo-2H-1,3,4-thiadiazin-5-yl)-1H-indole-2,3-dione 3-phenylhydrazone 
• 128230-98-8 1,3-dihydro-5-(3,6-dihydro-6-methyl-2-oxo-2H-1,3,4-thiadiazin-5-yl)-3-phenylimino-2H-indol-2-one 

Relevant academic research and scientific papers

INDOLE DERIVATIVES AS CRAC MODULATORS

Compounds of the formula I: or pharmaceutically acceptable salts thereof, wherein R1, R2, R3 and R4 are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of diseases associated with calcium release-activated calcium channels (CRAC).

Bicyclic heteroaryl thiazole compounds, cardiotonic compositions including the same, and their uses

Cardiotonic fused aromatic bicyclic ring substituted thiazole compounds and their salts, methods for increasing cardiac contractility in humans and other mammals by the use of said compounds, pharmaceutical compositions including said compounds and methods for compound preparation.

6-(4-thiazole) compounds, cardiotonic compositions including the same, and their uses

Cardiotonic fused aromatic bicyclic ring substituted thiazole compounds and their salts, methods for increasing cardiac contractility in humans and other mammals by the use of said compounds, pharmaceutical compositions including said compounds and methods for compound preparation.