65446-29-9Relevant academic research and scientific papers
New xanthine oxidase inhibitors from the fruiting bodies of Tyromyces fissilis
Mitomo, Shunsuke,Hirota, Mitsuru,Fujita, Tomoyuki
, p. 813 - 823 (2019)
Excessive uric acid production, which causes gout and hyperuricemia, can be blocked by inhibiting xanthine oxidase (XO). However, some agents to block on XO often cause side effects, thereby necessitating the identification of new inhibitors. During the s
Phenolic Lipids Derived from Cashew Nut Shell Liquid to Treat Metabolic Diseases
Sahin, Cigdem,Magomedova, Lilia,Ferreira, Thais A. M.,Liu, Jiabao,Tiefenbach, Jens,Alves, Priscilla S.,Queiroz, Fellipe J. G.,Oliveira, Andressa S. De,Bhattacharyya, Mousumi,Grouleff, Julie,Nogueira, Patrícia C. N.,Silveira, Edilberto R.,Moreira, Daniel C.,Leite, José Roberto Souza De Almeida,Brand, Guilherme D.,Uehling, David,Poda, Gennady,Krause, Henry,Cummins, Carolyn L.,Romeiro, Luiz A. S.
, p. 1961 - 1978 (2022/02/14)
Metabolic diseases are increasing at staggering rates globally. The peroxisome proliferator-activated receptors (PPARα/γ/δ) are fatty acid sensors that help mitigate imbalances between energy uptake and utilization. Herein, we report compounds derived from phenolic lipids present in cashew nut shell liquid (CNSL), an abundant waste byproduct, in an effort to create effective, accessible, and sustainable drugs. Derivatives of anacardic acid and cardanol were tested for PPAR activity in HEK293 cell co-transfection assays, primary hepatocytes, and 3T3-L1 adipocytes. In vivo studies using PPAR-expressing zebrafish embryos identified CNSL derivatives with varying tissue-specific activities. LDT409 (23) is an analogue of cardanol with partial agonist activity for PPARα and PPARγ. Pharmacokinetic profiling showed that 23 is orally bioavailable with a half-life of 4 h in mice. CNSL derivatives represent a sustainable source of selective PPAR modulators with balanced intermediate affinities (EC50 ～100 nM to 10 μM) that provide distinct and favorable gene activation profiles for the treatment of diabetes and obesity.
Synthesis and antidiabetic evaluation of 5-(2-methoxy-6-pentadecylbenzylidene)-3-alkyl/aryl substituted thiazolidine-2, 4-dione derivatives
Reddy, M. Upendar,Reddy, M.C. Somasekhara
, p. 1231 - 1236 (2018/05/29)
Compounds containing the thiazolidinedione moiety have been found to exhibit various pharmacological and biological activities viz., COX-2 inhibitor, antihyperglycemic, anti-inflammatory, antioxidant, cytotoxic, antimicrobial etc. The present paper descri
Synthesis, characterization and antimicrobial evaluation of (E)-N'-[(1-(2-methoxy-6-pentadecylbenzyl)-1H-1,2,3-triazol-4-yl]-methylene)benzohydrazide derivatives
Rambabu,Dubey,Ram,Balram
, p. 175 - 180 (2016/01/20)
Anacardic acid (pentadecyl salicylic acid) is a phenolic constituent present in cashew nut shell liquid (Anacardium occidentale L.) and exhibits antimicrobial properties. The present paper describes the synthesis, characterization and antimicrobial evaluation of hydrazone derivatives of anacardic acid (9a-l) linked with 1,2,3-triazole ring. All the newly synthesized compounds were determined by 1H NMR, mass and IR spectroscopy. Compounds 9d, 9e, 9h, 9i and 9j exhibited strong antifungal activity against the tested fungal strains viz., A. Niger and C. albicans.
Synthesis of azabicyclo[3.1.0]amine analogues of anacardic acid as potent antibacterial agents
Vempati, Ravi Kumar,Reddy,Alapati, Srinivasa Rao,Dubey
, p. 986 - 994 (2013/06/26)
Azabicyclo[3.1.0]amine analogues of anacardic acid (16a, 16b, 18a, 18b, 19 and 19b) were synthesized from anacardic acid and tested for their antibacterial activity against Gram positive and Gram negative bacteria. Most of the compounds are having potency at par with ampicillin and inferior with other standard drugs.
Synthesis and antibacterial activity of sulfonamide derivatives of anacardicacid mixture isolated from a natural product Cashew Nut Shell Liquid (CNSL)
Reddy, N. Subhakara,Rao, A. Srinivas,Chari, M. Adharvana,Kumar, V. Ravi,Jyothy,Himabindu
experimental part, p. 287 - 293 (2012/07/31)
Abstract: Synthesis and antibacterial activity of some novel sulfonamide derivatives of anacardic acid were (8a-8l) prepared from commercially available anacardic acid mixture (1a-d) isolated from a natural product Cashew Nut Shell Liquid (CNSL).Compounds (8a-8l) were tested for Gram positive and Gram negative bacterial cultures. Most of the compounds were showed active compared with standard drug ampicilline.
Synthesis and antibacterial activity of anacardic acid derivatives
Nallamillia, Subhakara Reddy,Kumara, V. Ravi,Himabindub,Rama,Aalapati, Srinivas Rao
experimental part, p. 626 - 632 (2012/05/05)
New anacardic acid derivatives (6a -6u) were prepared from commercially available anacardic acid and tested for Gram positive and Gram negative activities. Most compounds were found to be active compared to ampicillin.
Modulators (inhibitors/ activators) of histone acetyltransferases
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Page/Page column 2, (2008/06/13)
Disclosed are compounds of the formulae: and method of using the compounds to treat cancer, AIDS, HIV infection, and asthma.
COMPOUNDS CAPABLE OF ABSORBING ULTRAVIOLET RADIATION, COMPOSITIONS CONTAINING THEM AND PROCESSES FOR THEIR PREPARATION
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Page/Page column 30, (2008/06/13)
The molecules capable of absorbing ultraviolet radiation from the cashew nut shell liquid changes are the object of the present invention; it is also described the compositions responsible for protecting the surfaces and chemical processes for the referred molecules production.
Design, synthesis and biological evaluation of benzimidazole/benzothiazole and benzoxazole derivatives as cyclooxygenase inhibitors
Paramashivappa,Phani Kumar,Subba Rao,Srinivasa Rao
, p. 657 - 660 (2007/10/03)
We have synthesised a series of 2-[[2-alkoxy-6-pentadecylphenyl)methyl]thio]-1H-benzimidazoles/benzothiazoles and benzoxazoles from anacardic acid and investigated their ability to inhibit human cyclooxygenase-2 enzyme (COX-2). The active compounds were s
