65448-54-6Relevant academic research and scientific papers
Synthesis, characterization, and coordination chemistry of the 2-azaphenalenyl radical
Zheng, Shijun,Lan, Jie,Khan, Saeed I.,Rubin, Yves
, p. 5786 - 5791 (2007/10/03)
The 2-azaphenalenyl radical 2 has been synthesized and characterized by ESR spectroscopy. Variable-temperature ESR measurements were carried out on both the phenalenyl (1) and the 2-azaphenalenyl (2) radicals. The phenalenyl radical 1 has the known propen
New and Convenient Synthesis of 2-Substituted 2,3-Dihydro-1H-benzisoquinolin-1-ones
Sato, Ryu,Oikawa, Katsuyuki,Goto, Takehiko,Saito, Minoru
, p. 2238 - 2240 (2007/10/02)
Various 2-substituted 2,3-dihydro-1H-benzisoquinolin-1-ones were obtained in high yields by chemoselective reduction of 2-substituted 1H-benzisoquinoline-1,3(2H)-diones with sodium or zinc borohydride at room temperature.
Inhibitors of Bllod Platelet Aggregation. Activity of Some 1H-Benzisoquinolinecarboximidamides on the in Vivo Blood Platelet Aggregation Induced by Collagen
Beetz, Tom,Meuleman, Dick G.,Wieringa, Joop H.
, p. 714 - 719 (2007/10/02)
A series of 33-1H-benzisoquinolinecarboximidamides has been prepared and tested in the rat after intraperitoneal (ip) and/or oral (po) administration for their ability to inhibit the in vivo blood platelet aggregation induced by colagen.In this aggregation test, a considerable number of active compounds were found.Fourteen compounds were active when administred ip , five of which also exhibited significant po activity.One compound was toxic after ip administration but was found to be active after po administration without apparent toxicity.Itis thought that the solubility of the drug in water is an important factor for the resorption after oral administration and, hence, for its oral activity.
