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65469-41-2

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65469-41-2 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 65469-41-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,5,4,6 and 9 respectively; the second part has 2 digits, 4 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 65469-41:
(7*6)+(6*5)+(5*4)+(4*6)+(3*9)+(2*4)+(1*1)=152
152 % 10 = 2
So 65469-41-2 is a valid CAS Registry Number.

65469-41-2Downstream Products

65469-41-2Relevant articles and documents

Accepting the Invitation to Open Innovation in Malaria Drug Discovery: Synthesis, Biological Evaluation, and Investigation on the Structure-Activity Relationships of Benzo[b]thiophene-2-carboxamides as Antimalarial Agents

Pieroni, Marco,Azzali, Elisa,Basilico, Nicoletta,Parapini, Silvia,Zolkiewski, Michal,Beato, Claudia,Annunziato, Giannamaria,Bruno, Agostino,Vacondio, Federica,Costantino, Gabriele

, p. 1959 - 1970 (2017/03/17)

Malaria eradication is a global health priority, but current therapies are not always suitable for providing a radical cure. Artemisinin has paved the way for the current malaria treatment, the so-called Artemisinin-based Combination Therapy (ACT). However, with the detection of resistance to ACT, innovative compounds active against multiple parasite species and at multiple life stages are needed. GlaxoSmithKline has recently disclosed the results of a phenotypic screening of an internal library, publishing a collection of 400 antimalarial chemotypes, termed the “Malaria Box”. After analysis of the data set, we have carried out a medicinal chemistry campaign in order to define the structure-activity relationships for one of the released compounds, which embodies a benzothiophene-2-carboxamide core. Thirty-five compounds were prepared, and a description of the structural features responsible for the in vitro activity against different strains of P. falciparum, the toxicity, and the metabolic stability is herein reported.

Synthesis of Benzothienonaphthyridines

Kudo, Hirotaka,Takahashi, Kazufumi,Castle, Raymond N.,Lee, Milton L.

, p. 1009 - 1011 (2007/10/02)

3-Chlorobenzothiophene-2-carbonyl chloride reacted readily with 2-amino-, 3-amino, or 4-aminopyridine to give the corresponding amides.Photocyclization of the amides afforded the following lactams:benzothienonaphthyridin-6(5H)-one (14), benzothienonaphthyridin-6(5H)-one (7), benzothienonaphthyridin-6(5H)-one (11), and benzothienonaphthyridin-6(5H)-one (3).These lactams have been converted to other derivatives including in two instances the unsubstituted ring system.

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