65481-02-9Relevant articles and documents
Approaches to the Synthesis of the Mitomycins. A Route to the Mitosanes Involving Activated Cyclopropanes
Danishefsky, Samuel,Regan, John,Doehner, Robert
, p. 5255 - 5261 (2007/10/02)
The synthesis of (9R*,9aS*)-9-methyl>-9,9a-dihydro-5,7,8-trimethoxy-6-methyl-3H-pyrroloindole has been achieved.The key reaction involves intramolecular nucleophilic displacement of an activated cyclopropane.The modification of the electrophilicity of the diactivated cyclopropane by alteration of the geometric relationship of the carbonyl linkages with the bent bonds of the ring is an important feature of the study.