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Usage

Uses

Used in Veterinary Medicine:
2-(3,4-dichlorophenyl)-1H-indene-1,3(2H)-dione is used as an antiseptic and disinfectant for treating infections in livestock. Its ability to damage the DNA of microorganisms makes it effective in combating various infections.
Used in Human Medicine:
In human medicine, 2-(3,4-dichlorophenyl)-1H-indene-1,3(2H)-dione is used as a topical antiseptic for wound care. Its antimicrobial properties aid in preventing infection and promoting healing.
Used in Disinfection:
2-(3,4-dichlorophenyl)-1H-indene-1,3(2H)-dione is used as a disinfectant in various settings to eliminate microorganisms and maintain a hygienic environment.
It is crucial to handle and use 2-(3,4-dichlorophenyl)-1H-indene-1,3(2H)-dione with care due to its toxic nature, which can lead to skin and eye irritation. The use of Acriflavine is regulated in many countries to mitigate potential health hazards.

Upstream product

• 6287-38-3 3,4-dichlorobenzaldehyde 
• 184176-33-8 methyl o-[α-phenylsulfonyl]toluate 
• 87-41-2 2-benzofuran-1(3H)-one 

Relevant academic research and scientific papers

Formation of 2-arylindane-1,3-diones and 3-alkylphthalides from methyl o-[α-phenylsulfonyl]toluate

2-Aryl-1,3-indanedione and phthalide derivatives have attracted considerable interest due to their anticoagulant, parasiticidal and a range of biological activities. The synthesis of 2-aryl-1,3-indanedione by the condensation of the title sulfone with aryl aldehydes through an interesting pathway and a previously unreported approach to 3-alkylphthalide from C-alkylated derivatives of 1 under microwave and conventional heating conditions are described.

Hypolipidemic Activity of Indan-1,3-dione Derivatives in Rodents

A series of 2-substituted indan-1,3-dione derivatives, including alkyl (C-1-C-5), mono- and disubstituted phenyl, and other 2-aryl derivatives, were tested for hypolipidemic activity of CF1 male mice at 20 mg/kg per day.These derivatives reduced both serum cholesterol and triglycerides after 16 days of administration intraperitoneally. 2-(4-Methoxyphenyl)indan-1,3-dione was one of the more active compounds with 41percent reduction of serum cholesterol and 58percent reduction of serum triglyceride levels on day 16.This activity was confirmed in the rat after oral administration. 2-(2-Methylphenyl)- and 2-(4-chlorophenyl)indan-1,3-dione were effective in reducing serum triglyceride levels 58percent and 53percent, respectively, in mice.Serum cholesterol on day 16 was effectively reduced 46percent by 2-(2,4-dimethylphenyl)indan-1,3-dione.The indan-1,3-dione derivatives were more effective than clofibrate in lowering lipid levels in mice.A more detailed study on the effects of 2-(4-methoxyphenyl)indan-1,3-dione demonstrated that key enzymes in the de novo synthesis of lipids were inhibited by the drug lowering tissue levels of lipids but raising those in the feces.The alterations in lipid content of rat lipoprotein fractions by the drug appeared favorable.

New Possibilities of Applying Indane-1,3-Dione Derivatives.

The synthesis of a series of indane-1,3-dione and 2-aryl-indane-1,3-dione derivatives has been presented. The reaction of the title compounds with beta -nitrovinylbenzene, as well as nitration of 2-arylindanediones has been investigated. The products were tested on tomato leaves according to the screening test of three apical leaflets. The addition products of indane-1,3-dione and beta -nitrovinylbenzene proved to be active systemic fungicides. Their biological activity depended in magnitude on the nature and position of the substituent in the aryl group.