65490-17-7

Upstream product

• 6295-35-8 6-methoxy-4-methyl-chromen-2-one 
• 705-15-7 1-(2-hydroxy-5-methoxyphenyl)ethan-1-one 
• 1779-49-3 Methyltriphenylphosphonium bromide 

Downstream Products

• 1392836-27-9 2-((2S,4S)-1,2,3,4-tetrahydro-6-methoxy-4-methyl-2-(4-nitrophenyl)quinolin-4-yl)-4-methoxyphenol 
• 1392836-30-4 2-((2S,4S)-2-(3,4-dichlorophenyl)-6-methoxy-4-methyl-1,2,3,4-tetrahydroquinolin-4-yl)-4-methoxyphenol 
• 1416217-41-8 1-benzyl-6-chloro-4'-(2-hydroxy-5-methoxyphenyl)-6'-methoxy-4'-methyl-3',4'-dihydro-1'H-spiro[indoline-3,2'-quinolin]-2-one 
• 1610359-53-9 9-methoxy-4-methyl-1,2-diphenylspiro[4,5]deca-1,3,7,9-tetraen-6-one 

Relevant academic research and scientific papers

OH-directed alkynylation of 2-vinylphenols with ethynyl benziodoxolones: A fast access to terminal 1,3-enynes

The first direct alkynylation of 2-vinylphenols was developed. The rationally optimized hypervalent iodine reagent TIPS-EBX in combination with [(CpRhCl2)2] as a C-H-activating transition metal catalyst enables the construction of a variety of highly substituted 1,3-enynes in high yields of up to 98 %. This novel C-H activation method shows excellent chemoselectivity and exclusive (Z)-stereoselectivity, and it is also remarkably mild and tolerates a variety of functional groups. Furthermore, synthetic modifications of the resulting 1,3-enynes were demonstrated. To our knowledge, this is the first example for an OH-directed C-H alkynylation with hypervalent iodine reagents.

Rhodium(III)-catalyzed dearomatizing (3 + 2) annulation of 2-alkenylphenols and alkynes

Appropriately substituted 2-alkenylphenols undergo a mild formal [3C+2C] cycloaddition with alkynes when treated with a Rh(III) catalyst and an oxidant. The reaction, which involves the cleavage of the terminal C-H bond of the alkenyl moiety and the dearomatization of the phenol ring, provides a versatile and efficient approach to highly appealing spirocyclic skeletons and occurs with high selectivity.

Ethylene glycol as hydrogen donor for the syntheses of thymol analogues via hydrolysis of 4-methylcoumarins

Treatment of 4-methylcoumarins with potassium hydroxide in ethylene glycol resulted in the formation of the 'normal' 2-isopropenylphenols and/or the 'abnormal' 2-isopropylphenols depending on the nature of the substrates. The solvent ethylene glycol was b