65490-24-6

Basic information

• Product Name: ANHYDROCHLORTETRACYCLINE HYDROCHLORIDE, CAN BE USED AS SECONDARY STANDARD
• Synonyms: ANHYDROCHLORTETRACYCLINE HYDROCHLORIDE, CAN BE USED AS SECONDARY STANDARD;(4S,4aS,12aS)-7-Chloro-4-(diMethylaMino)-1,4,4a,5,12,12a-hexahydro-3,10,11,12a-tetrahydroxy-6-Methyl-1,12-dioxo-2-naphthacenecarboxaMide Hydrochloride;[4S-(4α,4aα,12aα)]-7-Chloro-4- (diMethylaMino)-1,4,4a,5,12,12a-hexahydro-3,10,11,12a-tetrahydroxy-6-Methyl-1,12-dioxo-2-naphthacenecarboxaMide Hydrochloride;AnhydroaureoMycin Hydrochloride;Anhydrochlortetracyline Hydrochloride
• CAS NO: 65490-24-6
• Molecular Formula: C22H22Cl2N2O7
• Molecular Weight: 497.32528
• Product Categories: Amines;Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 65490-24-6.mol
• Article Data: 2

Chemical Properties

• Melting Point: >250°C
• Appearance: /
• CAS DataBase Reference: ANHYDROCHLORTETRACYCLINE HYDROCHLORIDE, CAN BE USED AS SECONDARY STANDARD(CAS DataBase Reference)
• NIST Chemistry Reference: ANHYDROCHLORTETRACYCLINE HYDROCHLORIDE, CAN BE USED AS SECONDARY STANDARD(65490-24-6)
• EPA Substance Registry System: ANHYDROCHLORTETRACYCLINE HYDROCHLORIDE, CAN BE USED AS SECONDARY STANDARD(65490-24-6)

Safety Data

• Safety Statements: S24/25:Avoid contact with skin and eyes.
• Hazardous Substances Data: 65490-24-6(Hazardous Substances Data)

Usage

Chemical Properties

orange to red-brown crystalline powder

Uses

Anhydrochlortetracycline is the anhydro analogue and impurity of Chlortetracycline (C426500). Anhydrochlortetracycline is an antimicrobial and antibacterial.

Upstream product

• 64-72-2 chlortetracycline hydrochloride 

Relevant articles and documents

Semisynthetic analogues of anhydrotetracycline as inhibitors of tetracycline destructase enzymes

The synthesis and biological evaluation of semisynthetic anhydrotetracycline analogues as small molecule inhibitors of tetracycline-inactivating enzymes are reported. Inhibitor potency was found to vary as a function of enzyme (major) and substrate-inhibitor pair (minor), and anhydrotetracycline analogue stability to enzymatic and nonenzymatic degradation in solution contributes to their ability to rescue tetracycline activity in whole cell Escherichia coli expressing tetracycline destructase enzymes. Taken collectively, these results provide the framework for the rational design of next-generation inhibitor libraries en route to a viable and proactive adjuvant approach to combat the enzymatic degradation of tetracycline antibiotics.