65490-24-6

Basic information

• Product Name: ANHYDROCHLORTETRACYCLINE HYDROCHLORIDE, CAN BE USED AS SECONDARY STANDARD
• Synonyms: ANHYDROCHLORTETRACYCLINE HYDROCHLORIDE, CAN BE USED AS SECONDARY STANDARD;(4S,4aS,12aS)-7-Chloro-4-(diMethylaMino)-1,4,4a,5,12,12a-hexahydro-3,10,11,12a-tetrahydroxy-6-Methyl-1,12-dioxo-2-naphthacenecarboxaMide Hydrochloride;[4S-(4α,4aα,12aα)]-7-Chloro-4- (diMethylaMino)-1,4,4a,5,12,12a-hexahydro-3,10,11,12a-tetrahydroxy-6-Methyl-1,12-dioxo-2-naphthacenecarboxaMide Hydrochloride;AnhydroaureoMycin Hydrochloride;Anhydrochlortetracyline Hydrochloride
• CAS NO: 65490-24-6
• Molecular Formula: C22H22Cl2N2O7
• Molecular Weight: 497.32528
• Product Categories: Amines;Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 65490-24-6.mol

Chemical Properties

• Melting Point: >250°C
• Appearance: /
• CAS DataBase Reference: ANHYDROCHLORTETRACYCLINE HYDROCHLORIDE, CAN BE USED AS SECONDARY STANDARD(CAS DataBase Reference)
• NIST Chemistry Reference: ANHYDROCHLORTETRACYCLINE HYDROCHLORIDE, CAN BE USED AS SECONDARY STANDARD(65490-24-6)
• EPA Substance Registry System: ANHYDROCHLORTETRACYCLINE HYDROCHLORIDE, CAN BE USED AS SECONDARY STANDARD(65490-24-6)

Safety Data

• Safety Statements: S24/25:Avoid contact with skin and eyes.
• Hazardous Substances Data: 65490-24-6(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
Anhydrochlortetracycline hydrochloride, which can be used as a secondary standard, is used as an antimicrobial agent for treating bacterial infections. Its antibacterial properties make it effective against a wide range of bacteria, contributing to its use in the development of antibiotics and other pharmaceutical products.
Used in Research and Quality Control:
Anhydrochlortetracycline hydrochloride, which can be used as a secondary standard, is used as a reference material in research and quality control processes. Its well-defined purity and properties allow it to serve as a reliable standard for the accurate measurement and analysis of other substances in various applications.
Used in Environmental and Industrial Applications:
Anhydrochlortetracycline hydrochloride, which can be used as a secondary standard, is also utilized in environmental and industrial applications. Its antimicrobial properties can be employed to control bacterial growth in various settings, such as water treatment, agriculture, and industrial processes, ensuring cleanliness and safety.

Upstream product

• 64-72-2 chlortetracycline hydrochloride 

Relevant articles and documents

Semisynthetic analogues of anhydrotetracycline as inhibitors of tetracycline destructase enzymes

The synthesis and biological evaluation of semisynthetic anhydrotetracycline analogues as small molecule inhibitors of tetracycline-inactivating enzymes are reported. Inhibitor potency was found to vary as a function of enzyme (major) and substrate-inhibitor pair (minor), and anhydrotetracycline analogue stability to enzymatic and nonenzymatic degradation in solution contributes to their ability to rescue tetracycline activity in whole cell Escherichia coli expressing tetracycline destructase enzymes. Taken collectively, these results provide the framework for the rational design of next-generation inhibitor libraries en route to a viable and proactive adjuvant approach to combat the enzymatic degradation of tetracycline antibiotics.

INHIBITION AND DIAGNOSTICS OF EMERGING TETRACYCLINE RESISTANCE ENZYMES

The present disclosure provides compositions and methods for treating bacterial infections in a subject. The methods comprise administering a compound that binds a FAD-dependent flavoenzyme and a tetracycline, analog, derivative, or pharmaceutically acceptable salt thereof.