65499-01-6

Basic information

• Product Name: Methyl 2-oxo-3-phenylbutanoate
• Synonyms: Methyl 2-oxo-3-phenylbutanoate
• CAS NO: 65499-01-6
• Molecular Formula: C₁₁H₁₂O₃
• Molecular Weight: 192.21118
• Mol File: 65499-01-6.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: Methyl 2-oxo-3-phenylbutanoate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 2-oxo-3-phenylbutanoate(65499-01-6)
• EPA Substance Registry System: Methyl 2-oxo-3-phenylbutanoate(65499-01-6)

Safety Data

• Hazardous Substances Data: 65499-01-6(Hazardous Substances Data)

Usage

General Description

Methyl 2-oxo-3-phenylbutanoate is a chemical compound with the formula C11H12O3. It is an organic compound commonly used in the synthesis of pharmaceuticals and other organic molecules. It is a white to slightly yellow crystalline powder with a fruity odor. Methyl 2-oxo-3-phenylbutanoate is also known as Methyl phenylpyruvate and is primarily used in the production of fragrances and flavorings. It is also used as a precursor in the preparation of various pharmaceuticals and drugs. The compound is considered to be relatively stable and is not known to pose any significant health hazards under normal handling and use.

Upstream product

• 1248973-18-3 2-Hydroxy-3-phenyl-butyric acid methyl ester 
• 79435-70-4 1-((2R,5S)-5-Isopropyl-3,6-dimethoxy-2,5-dihydro-pyrazin-2-yl)-1-phenyl-ethanol 

Downstream Products

• 91828-65-8 (2R,3S)-3-Phenyl-2-((S)-3,3,3-trifluoro-2-methoxy-2-phenyl-propionyloxy)-butyric acid methyl ester 
• 91828-65-8 (2S,3R)-3-Phenyl-2-((S)-3,3,3-trifluoro-2-methoxy-2-phenyl-propionyloxy)-butyric acid methyl ester 
• 91828-71-6 (2R,3R)-2-Hydroxy-3-phenylbutyric acid methyl ester 
• 91828-70-5 methyl (-)-syn-2-hydroxy-3-phenylbutanoate 

Relevant articles and documents

Catalyst and method for isomerization

A catalyst for isomerization consisting essentially of a salt or complex salt represented by the formula: where M is a metal of Group IB, IIA, IIB or VIII of the periodic table, L is a ligand, Y is a conjugated base of a Bronsted acid, m is 0, 1, 2, 3 or 4 and n is 1, 2 or 3.

ENANTIOSELECTIVE SYNTHESIS OF NON-PROTEINOGENIC AMINO ACIDS VIA METALLATED BIS-LACTIM ETHERS OF 2,5-DIKETOPIPERAZINES

Bis-lactim ethers 1 of 2,5-diketopiperazines contain a chiral inducing center, an acidic CH-bond and two sites susceptible to hydrolysis.They react with BuLi to give Li compounds of type 4, 15, 29 or 32, which possess a prochiral C atom.They readily add electrophiles (such as alkylating agents or carbonyl compounds) with unusually high diastereoface differentiation.In many cases the d.e-value (d.e. = diastereomeric excess = asymmetric induction) of the adduct exceeds 95percent.On hydrolysis the adducts are cleaved liberating the chiral auxiliary (used to build up the bis-lactim ether 1) and the target molecules, the optically active amino acid methyl esters of type 8, 19, 25 or 36.The two amino acid esters are separable either by fractional distillation or (eventually after further hydrolysis to amino acids) by chromatography.Transition state models are discussed that could explain the exceptionally high asymmetric induction and the predictability of the induced configuration.