65499-01-6

Usage

Uses

Used in Pharmaceutical Industry:
Methyl 2-oxo-3-phenylbutanoate is used as a precursor in the preparation of various pharmaceuticals and drugs. Its chemical structure allows it to be a key intermediate in the synthesis of a range of medicinal compounds.
Used in Fragrance and Flavoring Industry:
Methyl 2-oxo-3-phenylbutanoate is used as a component in the production of fragrances and flavorings. Its fruity odor makes it a valuable ingredient in creating pleasant scents and tastes for a variety of products.
Methyl 2-oxo-3-phenylbutanoate is considered to be relatively stable and is not known to pose any significant health hazards under normal handling and use.

Upstream product

• 79435-70-4 1-((2R,5S)-5-Isopropyl-3,6-dimethoxy-2,5-dihydro-pyrazin-2-yl)-1-phenyl-ethanol 
• 1248973-18-3 2-Hydroxy-3-phenyl-butyric acid methyl ester 

Downstream Products

• 91828-70-5 methyl (-)-syn-2-hydroxy-3-phenylbutanoate 
• 91828-71-6 (2R,3R)-2-Hydroxy-3-phenylbutyric acid methyl ester 
• 91828-65-8 (2R,3S)-3-Phenyl-2-((S)-3,3,3-trifluoro-2-methoxy-2-phenyl-propionyloxy)-butyric acid methyl ester 
• 91828-65-8 (2S,3R)-3-Phenyl-2-((S)-3,3,3-trifluoro-2-methoxy-2-phenyl-propionyloxy)-butyric acid methyl ester 

Relevant academic research and scientific papers

Catalyst and method for isomerization

A catalyst for isomerization consisting essentially of a salt or complex salt represented by the formula: where M is a metal of Group IB, IIA, IIB or VIII of the periodic table, L is a ligand, Y is a conjugated base of a Bronsted acid, m is 0, 1, 2, 3 or 4 and n is 1, 2 or 3.

The Use of Microorganisms in Organic Synthesis. IV. Microbiological Asymmetric Reduction of Methyl 3-Phenyl 2-Oxobutyrate

The synthesis of optically active α-hydroxy β-methyl esters V by means of microbiological reduction of the corresponding α-keto β-methyl esters IV was carried out.Methyl 3-phenyl-2-oxobutyrate 3 was found to be reduced by a variety of yeasts to the α-hydr

ENANTIOSELECTIVE SYNTHESIS OF NON-PROTEINOGENIC AMINO ACIDS VIA METALLATED BIS-LACTIM ETHERS OF 2,5-DIKETOPIPERAZINES

Bis-lactim ethers 1 of 2,5-diketopiperazines contain a chiral inducing center, an acidic CH-bond and two sites susceptible to hydrolysis.They react with BuLi to give Li compounds of type 4, 15, 29 or 32, which possess a prochiral C atom.They readily add electrophiles (such as alkylating agents or carbonyl compounds) with unusually high diastereoface differentiation.In many cases the d.e-value (d.e. = diastereomeric excess = asymmetric induction) of the adduct exceeds 95percent.On hydrolysis the adducts are cleaved liberating the chiral auxiliary (used to build up the bis-lactim ether 1) and the target molecules, the optically active amino acid methyl esters of type 8, 19, 25 or 36.The two amino acid esters are separable either by fractional distillation or (eventually after further hydrolysis to amino acids) by chromatography.Transition state models are discussed that could explain the exceptionally high asymmetric induction and the predictability of the induced configuration.