65501-71-5

Basic information

• Product Name: 1-OCTANESULFONAMIDE
• Synonyms: 1-OCTANESULFONAMIDE;Nsc23386;Octane-1-sulfonamide
• CAS NO: 65501-71-5
• Molecular Formula: C₈H₁₉NO₂S
• Molecular Weight: 193.307
• Mol File: 65501-71-5.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 303.7°Cat760mmHg
• Flash Point: 137.5°C
• Appearance: /
• Density: 1.043g/cm³
• Vapor Pressure: 0.000917mmHg at 25°C
• Refractive Index: 1.468
• PKA: 10.86±0.60(Predicted)
• CAS DataBase Reference: 1-OCTANESULFONAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-OCTANESULFONAMIDE(65501-71-5)
• EPA Substance Registry System: 1-OCTANESULFONAMIDE(65501-71-5)

Safety Data

• Hazardous Substances Data: 65501-71-5(Hazardous Substances Data)

Usage

General Description

1-Octanesulfonamide is a chemical compound with the molecular formula C8H19NO2S. It is a clear, colorless to yellowish liquid commonly used as an additive in many industrial processes. 1-Octanesulfonamide is known for its ability to act as a surfactant, emulsifier, and dispersant, making it useful in a variety of applications such as in the production of plastics, resins, adhesives, and lubricants. It is also used in the formulation of certain personal care products, as well as in the textile and agricultural industries. Additionally, 1-Octanesulfonamide is valued for its high thermal stability and chemical resistance, making it a versatile and important chemical in many industrial settings.

InChI:InChI=1/C8H19NO2S/c1-2-3-4-5-6-7-8-12(9,10)11/h2-8H2,1H3,(H2,9,10,11)

Upstream product

• 7795-95-1 octane-1-sulfonyl chloride 
• 19942-78-0 octyl thiocyanate 
• 111-83-1 1-bromo-octane 
• 98487-74-2 octane-1-sulfonyl azide 
• 76-63-1 allytriphenyltin 

Downstream Products

• 117290-21-8 [2-(Octane-1-sulfonylamino)-2-oxo-ethyl]-carbamic acid benzyl ester 
• 117290-27-4 [4-(Octane-1-sulfonylamino)-4-oxo-butyl]-carbamic acid benzyl ester 
• 5454-98-8 N-phenyloctane-1-sulfonamide 
• 1609252-29-0 (Z)-N-(2-cyano-3-phenylprop-2-en-1-yl)-octanesulfonamide 
• 944270-06-8 (2R)-N-benzyloxycarbonyl(octanesulfonyl pyrrolidine-2-carboxamide) 

Relevant articles and documents

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Synthesis of Sultams and Cyclic N-Sulfonyl Ketimines via Iron-Catalyzed Intramolecular Aliphatic C-H Amidation

Cyclic sulfonamides (sultams) play a unique role in drug discovery and synthetic chemistry. A direct synthesis of sultams by an intramolecular C(sp3)-H amidation reaction using an iron complex in situ derived from Fe(ClO4)2 and aminopyridine ligand is reported. This strategy features a readily available catalyst and tolerates a broad variety of substrates as demonstrated by 22 examples (up to 89% yield). A one-pot iron-catalyzed amidation/oxidation procedure for the synthesis of cyclic N-sulfonyl ketimines is also realized with up to 92% yield (eight examples). The synthetic utility of the method is validated by a gram-scale reaction and derivatization of the products to ring-fused sultams.

Synthesis and investigation of inhibition effect of fluorinated sulfonamide derivatives on carbonic anhydrase

Series of perfluoroalkanesulfonamides 1, sodium salt of perfluoroalkanesulfonamides 2 and polyfluoroalkanesulfonamides 3 derivatives were synthesized and characterized by 1H NMR, 13C NMR, 19F NMR, IR and HRMS. Inhibition effects of these compounds on bovine carbonic anhydrase (bCA) and human carbonic anhydrase isoenzyme II (hCA) have been investigated. Comparing IC50 values of the synthesized molecules 1, 2 and 3, it has been found that compound 2b is a more potent inhibitor than acetazolamide on hCA. Moreover 2b does not present cellular toxicity on sheep red globules.