65518-40-3

Usage

Uses

Used in Pharmaceutical Industry:
Phenyl(pyridin-2-yl)methanone N-phenylthiosemicarbazone is used as a potential therapeutic agent for its antimicrobial and antifungal properties. It has shown effectiveness in inhibiting the growth of various microorganisms, making it a candidate for the development of new antimicrobial and antifungal drugs.
Used in Oncology:
In the field of oncology, phenyl(pyridin-2-yl)methanone N-phenylthiosemicarbazone is used as a potential anticancer agent. Its ability to inhibit the growth of cancer cells has been demonstrated, suggesting that it could be developed into a novel treatment for various types of cancer.
Used in Antioxidant Applications:
Phenyl(pyridin-2-yl)methanone N-phenylthiosemicarbazone is also used as an antioxidant, which can help protect cells from damage caused by reactive oxygen species. This property makes it a potential candidate for the development of antioxidant supplements or treatments for conditions associated with oxidative stress.

Upstream product

• 91-02-1 phenyl(pyridin-2-yl)methanone 
• 5351-69-9 4-Phenyl-3-thiosemicarbazide 
• 103-72-0 phenyl isothiocyanate 
• 645-48-7 1-phenyl-3-thiosemicarbazide 

Relevant academic research and scientific papers

Crystallographic, spectroscopic and theoretical investigations on Ni(II) complexes of a tridentate NNS donor thiosemicarbazone

Five new nickel(II) complexes [Ni(L)NCS] (1b), [Ni(L)N3] (2), [Ni(L)N(CN)2] (3), [Ni(L)OAc] (4) and [Ni(HL)SO4] (5) of a thiosemicarbazone HL (where HL = 2-benzoylpyridine-N(4)-phenylthiosemicarbazone) including pseudohali

Platinum complex taking 2-benzoylpyridine thiosemicarbazone as ligand as well as synthesis method and application of platinum complex

The invention discloses a thiosemicarbazone platinum complex taking 2-benzoyl pyridine as a ligand as well as a synthesis method and application of the thiosemicarbazone platinum complex. 2-benzoyl pyridine and thiosemicarbazone are selected for condensat

FTO small-molecule inhibitor gold complex and synthesis method thereof

The invention discloses an FTO small molecule inhibitor gold complex and a synthetic method thereof. The synthetic method comprises the steps that 2-benzoylpyridine and thiosemicarbazide are taken, mixed and dissolved in methyl alcohol, concentrated sulfu

Gallium(iii)-2-benzoylpyridine-thiosemicarbazone complexes promote apoptosis through Ca2+ signaling and ROS-mediated mitochondrial pathways

Ga(iii) compounds are highly promising candidates for antitumor therapy. The level of intracellular reactive oxygen species (ROS) is significantly increased after Ga(iii) complex treatment, but these complexes are redox-inactive. To investigate the effect

Synthesis, antiproliferative activity and mechanism of gallium(III)-thiosemicarbazone complexes as potential anti-breast cancer agents

Five thiosemicarbazone ligands were synthesized and characterized by condensation with different aldehydes or ketones by 4-phenylthiosemicarbazone. The representative dichlorido[2-(Di-2-pyridinylmethylene)-Nphenylhydrazinecarbothioamide-N,N,S]-gallium(III

Stabilization of CuII-I Bonds Using 2-Benzoylpyridine Thiosemicarbazones - Synthesis, Structure, Spectroscopy, Fluorescence, and Cyclic Voltammetry

The reactions of copper(I) iodide with N1-substituted 2-benzoylpyridine thiosemicarbazones [(C6H5)(C5H4N)C2=N3-N2H-C(=S)-N1HR (R = Me, HLMe; Et,

Structure-activity studies of 4-phenyl-substituted 2′-benzoylpyridine thiosemicarbazones with potent and selective anti-tumour activity

2′-Benzoylpyridine thiosemicarbazones (BpT) are effective iron chelators and display potent anti-proliferative activity against tumour cells. In order to gain greater insight into the structure-activity relationships of the BpT chelators, ten new analogue

Synthesis, cytotoxic and antimalarial activities of benzoyl thiosemicarbazone analogs of isoquinoline and related compounds

Thiosemicarbazone analogs of papaveraldine and related compounds 1-6 were synthesized and evaluated for cytotoxic and antimalarial activities. The cytotoxic activity was tested against HuCCA-1, HepG2, A549 and MOLT-3 human cancer cell lines. Thiosemicarba

THIOSEMICARBAZONE COMPOUNDS AND USE THEREOF

A method of treating a proliferative disease in a vertebrate, the method comprising administering to the vertebrate a therapeutically effective amount of at least one compound of formula (I) (I) wherein R1 is selected from H, C1-6 alkyl, C2-6 alkenyl and phenyl; R2 is selected from H, C1-6 alkyl, C2-6 alkenyl and phenyl; wherein R1 and R2 are the same or different, or a salt, hydrate, or iron complex thereof, or a pharmaceutical composition comprising said compound, salt, hydrate or iron complex and a pharmaceutically acceptable carrier, diluent or excipient.

Spectral characterization of iron(III) complexes of 2-benzoylpyridine N(4)-substituted thiosemicarbazones

Three iron(III) complexes (1-3) of 2-benzoylpyridine N(4)-phenyl thiosemicarbazone (HL1) and one iron(III) complex (4) of 2-benzoylpyridine N(4)-cyclohexyl thiosemicarbazone (HL2) were synthesized and characterized by means of different physicochemical techniques viz., molar conductivity measurements, magnetic susceptibility studies and electronic, infrared and EPR spectral studies. The analytical data and the molar conductance measurements of the complexes reveal that two molecules of the ligand and the anion are coordinated to the metal atom in all the four complexes. The magnetic moments of the complexes suggest that they are of low spin. From the infrared spectra of the ligands and the complexes it is confirmed that the ligands coordinate to iron(III) as an anion coordinating via the azomethine nitrogen, pyridyl nitrogen, and the thiolate sulphur. The EPR spectra of the complexes in the polycrystalline state at 298 and 110 K and in DMF solution at 110 K were recorded and all the spectra show three g values indicating that these complexes have rhombic distortion. All the iron(III) complexes in DMF solution at 110 K have similar anisotropic spectra with almost the same gav values, indicating that the bonding in all the complexes is similar and is unaffected by the coordination of the anion.