6552-46-1

Basic information

• Product Name: alpha-cyclopropyl-4-methylbenzyl alcohol
• Synonyms: alpha-cyclopropyl-4-methylbenzyl alcohol;α-Cyclopropyl-4-methylbenzenemethanol;cyclopropyl(4-methylphenyl)methano
• CAS NO: 6552-46-1
• Molecular Formula: C₁₁H₁₄O
• Molecular Weight: 162.22826
• EINECS: 229-473-3
• Mol File: 6552-46-1.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: alpha-cyclopropyl-4-methylbenzyl alcohol(CAS DataBase Reference)
• NIST Chemistry Reference: alpha-cyclopropyl-4-methylbenzyl alcohol(6552-46-1)
• EPA Substance Registry System: alpha-cyclopropyl-4-methylbenzyl alcohol(6552-46-1)

Safety Data

• Hazardous Substances Data: 6552-46-1(Hazardous Substances Data)

Usage

Chemical Classification

Cyclopropyl-containing alcohol

Structure

Cyclopropyl group attached to a 4-methylbenzyl moiety

Properties

Unique reactivity due to cyclopropyl group
Versatile building block in organic synthesis
Potential applications in drug development

Applications

Synthesis of organic compounds
Drug and pharmaceutical development

Interest in Research

Studying reactivity and behavior of cyclopropyl-containing compounds

Overall

Diverse potential uses and applications in scientific and industrial settings

Upstream product

• 106-38-7 para-bromotoluene 
• 1489-69-6 Cyclopropanecarboxaldehyde 
• 23719-80-4 cyclopropylmagnesium bromide 
• 104-87-0 4-methyl-benzaldehyde 
• 7143-76-2 cyclopropyl-p-tolyl-methanone 
• 4333-56-6 cyclopropyl bromide 

Downstream Products

• 104375-68-0 N-(4-toluenesulfonyl)-2-(4-methylphenyl)pyrrolidine 

Relevant articles and documents

CuBr2-catalyzed ring opening/formylation reaction of cyclopropyl carbinols with DMF to synthesize formate esters

An unprecedented protocol for the synthesis of formate esters has been developed by employing N,N-dimethylformamide (DMF) as both the source of CHO and solvent. This reaction undergoes ring opening of the cyclopropyl carbinols and in situ formation of homoallylic alcohols, which reacts with DMF to give the desired products. The substrate cyclopropyl carbinols with different groups participate smoothly in this process and the desired products are obtained in moderate to good yields.

Regiospecific Nucleophilic Substitution in Cyclopropylcarbinols. Stereospecific Opening of the Cyclopropane Ring

Reactions of cyclopropylcarbinols with hydrobromic acid and the triphenylphosphine-tetrabromomethane complex at 0°C result in stereospecific opening of the cyclopropane ring with formation of trans-homoallyl bromides.