65523-68-4

Upstream product

• 4214-76-0 5-nitro-pyridin-2-ylamine 
• 98-59-9 p-toluenesulfonyl chloride 
• 4487-59-6 2-bromo-5-nitropyridine 
• 70-55-3 toluene-4-sulfonamide 

Downstream Products

• 869109-51-3 ethyl 5-[2-{[(4-methylphenyl)sulfonyl]imino}-5-nitropyridine-1(2H)-yl]-4-oxohexanoate 
• 899438-82-5 N-(5-aminopyridin-2-yl)-4-methylbenzenesulfonamide 
• 869109-52-4 ethyl (2E)-5-[2-{[(4-methylphenyl)sulfonyl]imino}-5-nitropyridin-1(2H)-yl]-4-oxohexen-2-oate 
• 869109-34-2 N-{1-[2-(3-methoxycyclobutyl)-1-methyl-2-oxoethyl]-5-nitro-1H-pyridin-2-ylidene}-4-methylbenzenesulfonamide 
• 869109-40-0 N-{1-[2-(3-hydroxycyclobutyl)-1-methyl-2-oxoethyl]-5-nitro-1H-pyridin-2-ylidene}-4-methylbenzenesulfonamide 

Relevant academic research and scientific papers

Copper-mediated n-heteroarylation of primary sulfonamides: Synthesis of mono-n-heteroaryl sulfonamides

"Figure Presented" We describe the coupling of primary sulfonamides and various halogenated heterocyclic cores, with an emphasis on 2-heteroaryl halides, via copper catalysis. These studies enabled the synthesis of many new mono-N-heteroaryl sulfonamides.

AROMATIC SULFONE COMPOUND AS ALDOSTERONE RECEPTOR MODULATOR

The present invention provides a compound represented by the following formula (I): [wherein, A represents a group of the following formula (A-1): etc., R1 and R2 each independently represent a hydrogen atom etc., Z represents CR3 etc., W represents CR4 etc., Q represents CR5 etc., R3, R4 and R5 each independently represent a hydrogen atom etc., Y represents an oxygen atom or sulfur atom, X represents an oxygen atom etc. and B represents an optionally substituted aryl group or optionally substituted heteroaryl group], the prodrug thereof or the pharmaceutically acceptable salt thereof for preventing or treating various diseases such as hypertesion, cerebral stroke, cardiac failure, etc.

IMIDAZOPYRIDINE COMPOUND

The present invention provides an imidazopyridine compound represented by formula (I), wherein R1 and R2 each independently represent a C1-6 alkyl group et al; R3 and R4 each independently represent a hydrogen atom, a methyl et al; Ar1 is a divalent substituent representing a monocyclic or bicyclic, 3- to 8-membered aromatic or aliphatic heterocyclic group et al; Ar2 represents an aromatic carbocyclic group, or an aromatic heterocyclic group; W represents -(CH2)m et al, and m indicates an integer of from 0 to 10. This compound acts as a melanin concentrating hormone receptor antagonist, and is useful as treating agents for obesity.

IMIDAZOPYRIDINE DERIVATIVES

The invention provides imidazopyridine derivatives represented by the general formula [I] [in which R1 and R2 may be the same or different and stand for C1-6 alkyl or the like, R3 and R4 stand for hydrogen atom, methyl group or the like, W stands for mono- or bi-cyclic 3- to 8-membered aromatic or aliphatic heterocycle or the like, and Ar stands for optionally substituted aromatic heterocycle or the like]. These compounds act as melanin-concentrating hormone receptor antagonist and are useful as medicines for central nervous system disorders, cardiovascular system disorders and metabolic disorders.