655235-70-4Relevant academic research and scientific papers
Design and Synthesis of Peptidomimetic Protein Farnesyltransferase Inhibitors as Anti-Trypanosoma brucei Agents
Ohkanda, Junko,Buckner, Frederick S.,Lockman, Jeffrey W.,Yokoyama, Kohei,Carrico, Dora,Eastman, Richard,De Luca-Fradley, Kate,Davies, Wendy,Croft, Simon L.,Van Voorhis, Wesley C.,Gelb, Michael H.,Sebti, Sa?d M.,Hamilton, Andrew D.
, p. 432 - 445 (2007/10/03)
On the basis of the structure of the CVIM tetrapeptide substrate of mammalian protein farnesyltransferase, a series of imidazole-containing peptidomimetics was designed and synthesized, and their inhibition activity against Trypanosoma brucei protein farn
Peptidomimetic inhibitors of protein farnesyltransferase show potent antimalarial activity
Ohkanda, Junko,Lockman, Jeffrey W.,Yokoyama, Kohei,Gelb, Michael H.,Croft, Simon L.,Kendrick, Howard,Harrell, Maria Isabel,Feagin, Jean E.,Blaskovich, Michelle A.,Sebti, Said M.,Hamilton, Andrew D.
, p. 761 - 764 (2007/10/03)
Malaria continues to represent a very serious health problem in the tropics. The current methods of clinical treatment are showing deficiencies due to the increased incidence of resistance in the parasite. In the present paper we report the design, synthe
