655245-80-0Relevant academic research and scientific papers
Synthesis and evaluation of optically pure dioxolanes as inhibitors of hepatitis C virus RNA replication
Bera, Sanjib,Malik, Leila,Bhat, Balkrishen,Carroll, Steven S.,MacCoss, Malcolm,Olsen, David B.,Tomassini, Joanne E.,Eldrup, Anne B.
, p. 4455 - 4458 (2007/10/03)
A series of optically pure 1,3-dioxolane nucleoside mimics was synthesized by a synthetic route that allowed incorporation of a 5R-methyl substituent from commercially available starting materials. The pyrrolo[2,3-d]pyrimidine heterocycle was chosen as a
Divergent Asymmetric Syntheses of Dioxolane Nucleoside Analogues
Evans, Colleen A.,Dixit, Dilip M.,Siddiqui, M. Arshad,Jin, Haolun,Tse, H. L. Allan,et al.
, p. 2319 - 2322 (2007/10/02)
Oxidative degradation of benzyloxymethylacetals derived from D-mannitol or L-ascorbic acid provides dioxolane intermediate 6 and 7 useful in the synthesis of all the stereoisomers of dioxolane nucleoside analogues.
