655246-35-8Relevant academic research and scientific papers
Synthetic studies on oligosaccharides composed of 5-thioglucopyranose units
Morii, Yasuharu,Matsuda, Hiroko,Ohara, Keiichiro,Hashimoto, Masaru,Miyairi, Kazuo,Okuno, Toshikatsu
, p. 5113 - 5144 (2007/10/03)
Glycosylation reactions of 5-thioglucopyranosyl trichloroacetimidates bearing ethereal protective groups at the 2-O-position 14-15, and 37 proceed smoothly to give α-glycosides stereoselectively by using a catalytic amount of silyl triflate. This methodol
Application of Site-Directed Lipase Mutants on Regioselective Acylation of Monosaccharides
Cipolla, Laura,Lotti, Marina,De Gioia, Luca,Nicotra, Francesco
, p. 631 - 644 (2007/10/03)
Mutants F344V and F345V of Candida rugosa lipasel (CRL1) were tested in acylation reactions of monosaccharide derivatives 1-8, in order to study the regioselectivity, and the substrate specificity of lipase variants towards unnatural substrates, such as carbohydrates. Mutant F344V showed a better reaction kinetics and/or regioselectivity then the wild type enzyme with several substrates while mutant F345V was inefficient in most cases. With the aim of correlating experimental data with the structural features of the enzyme and substrates, the interaction of substrates methyl 4,6-O-benzylidene-α- D-glucopyranoside (5a) and 4,6-O-benzylidene-α-D-galactopyranoside (6a) with the wild type enzyme and the mutant F344V was investigated, using a molecular modelling approach.
