655246-56-3Relevant academic research and scientific papers
Peptoidic amino- and guanidinium-carrier systems: Targeted drug delivery into the cell cytosol or the nucleus
Schr?der, Tina,Niemeier, Nicole,Afonin, Sergii,Ulrich, Anne S.,Krug, Harald F.,Br?se, Stefan
, p. 376 - 379 (2008/09/18)
Efficient drug delivery is essential for many therapeutic applications. Some cell-penetrating peptides, peptide mimetics, and peptoids express transport function that, however, lack in most cases specific intracellular destination. In this study, carrier-peptoids with either amino or guanidinium side chains, were investigated with regard to their cellular uptake, toxicity, and intracellular localization. Transport specifically to the cytosol or to the nuclei was observed, thus providing a powerful tool for targeted drug delivery.
Cell penetrable peptoid carrier vehicles: synthesis and evaluation.
Peretto, Ilaria,Sanchez-Martin, Rosario M,Wang, Xui-hong,Ellard, John,Mittoo, Stifun,Bradley, Mark
, p. 2312 - 2313 (2007/10/03)
Using a highly efficient solid-phase route a series of fluorescein conjugated peptoid oligomers were synthesised and observed to display remarkable cell penetrating properties, offering the possibility of highly efficient cellular targeting.
