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Usage

Uses

Used in Organic Synthesis:
Benzenethiol, 3,4-diamino(9CI) is utilized as a reagent in organic synthesis for the preparation of various organic compounds. Its unique chemical structure allows for versatile reactions, making it a valuable component in the synthesis of pharmaceuticals, agrochemicals, and other specialty chemicals.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, Benzenethiol, 3,4-diamino(9CI) serves as a precursor to the development of new drugs. Its unique structure can be modified to create novel therapeutic agents with potential applications in treating various diseases and conditions.
Used in Agrochemical Industry:
Benzenethiol, 3,4-diamino(9CI) also finds use in the agrochemical industry, where it can be employed as a precursor to the synthesis of pesticides, herbicides, and other crop protection agents. Its unique chemical properties can contribute to the development of more effective and environmentally friendly agrochemicals.

Upstream product

• 80983-47-7 4-amino-3-nitrobenzenethiol 
• 88-74-4 2-nitro-aniline 
• 54029-45-7 2-nitro-4-thiocyanoaniline 

Relevant academic research and scientific papers

Ratiometric SERS imaging and selective biosensing of nitric oxide in live cells based on trisoctahedral gold nanostructures

Herein, a ratiometric SERS probe was created for monitoring nitric oxide (NO) by designing a novel molecule, 3,4-diaminobenzene-thiol, and immobilizing this molecule onto trisoctahedral gold nanostructures with superior SERS capability. The established probe possessed good selectivity and biocompatibility, high sensitivity and accuracy, thus enabling imaging and biosensing of NO in live cells.

Synthesis of 3,4-diaminobenzenethiol and its application in gold nanoparticle-based colorimetric determination of copper ions

An improved synthetic method for the synthesis of 3,4-diaminobenzenethiol is presented. The practical application of this reagent as a new ligand for gold nanoparticles for the rapid detection of Cu2+ in water is demonstrated. The method is shown to have high sensitivity and selectivity. Well-defined peaks, proportional to the concentration of the corresponding Cu2+, were observed from 0.5 μM to 2 μM, and the recovery was in the range of 92-109%. This method provides a facile route for Cu2+ analysis.

On benzo[b][1,4]diazepinium-olates, -thiolates and -carboxylates as anti-Hueckel mesomeric betaines

2,3-Diaminophenol 4, 3,4-diaminophenol 5, 4-methoxy-1,2-diaminobenzene 6, 3,4-diaminobenzenthiol 7, 2,3-diaminobenzoic acid 8, and 3,4-diaminobenzoic acid 9 were reacted with 2,4-pentanedione to yield the corresponding benzo[b][1,4]diazepinium salts, respectively. The hydroxy-benzo[b][1,4]diazepinium salts 17 and 18 do not form mesomeric betaines (MB) on deprotonation. Instead, they are converted into the diimines 24 and 25. By contrast, the 7-mercaptobenzo[b][1,4]diazepinium salt 20 yields the corresponding thiolate on increasing the pH of the solution. This MB, which possesses 4n π-electrons, does not fit into the classification system of heterocyclic mesomeric betaines accepted today. Deprotonation of the betaine results in the formation of an instable anionic thiolate 31 which oxidizes immediately to the disulfide 32. The carboxy derivatives 21 and 22 readily form cross-conjugated mesomeric betaines. Whereas the diimine 34 proved to be instable, the sodium salt of the diimine 36 was unambiguously characterized. An X-ray single crystal analysis of 22 as its picrate is presented in order to gain additional insights into these 4n π-electron systems.