65538-27-4Relevant academic research and scientific papers
Late-Stage β-C(sp3)-H Deuteration of Carboxylic Acids
Mal, Sourjya,Uttry, Alexander,Van Gemmeren, Manuel
supporting information, p. 10895 - 10901 (2021/08/03)
Carboxylic acids are highly abundant in bioactive molecules. In this study, we describe the late-stage β-C(sp3)-H deuteration of free carboxylic acids. On the basis of the finding that C-H activation with our catalysts is reversible, the de-deuteration process was first optimized. The resulting method uses ethylenediamine-based ligands and can be used to achieve the desired deuteration when using a deuterated solvent. The reported method allows for the functionalization of a wide range of free carboxylic acids with diverse substitution patterns, as well as the late-stage deuteration of bioactive molecules and related frameworks and enables the functionalization of nonactivated methylene β-C(sp3)-H bonds for the first time.
Polarization IR spectra of the hydrogen bond in phenylacetic acid crystals: H/D isotopic effects - Temperature and polarization effects
Flakus, Henryk T.,Chelmecki, Michal
, p. 1867 - 1880 (2007/10/03)
This paper deals with experimental studies and with quantitative interpretation of the polarized IR crystalline spectra of phenylacetic acid and of its deuterium isotopomers d2 and d7. The spectra were measured in the νO-H
