6555-27-7

Basic information

• Product Name: ()-2-amino-3-(4-hydroxy-3-methoxyphenyl)-2-methylpropiononitrile
• Synonyms: (1)-2-Amino-3-(4-hydroxy-3-methoxyphenyl)-2-methylpropiononitrile; 2-amino-3-(4-hydroxy-3-methoxyphenyl)-2-methylpropanenitrile
• CAS NO: 6555-27-7
• Molecular Formula: C₁₁H₁₄N₂O₂
• Molecular Weight: 206.2411
• EINECS: 229-484-3
• Mol File: 6555-27-7.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 388.6°C at 760 mmHg
• Flash Point: 188.8°C
• Density: 1.179g/cm³
• Vapor Pressure: 1.36E-06mmHg at 25°C
• Refractive Index: 1.566
• CAS DataBase Reference: ()-2-amino-3-(4-hydroxy-3-methoxyphenyl)-2-methylpropiononitrile(CAS DataBase Reference)
• NIST Chemistry Reference: ()-2-amino-3-(4-hydroxy-3-methoxyphenyl)-2-methylpropiononitrile(6555-27-7)
• EPA Substance Registry System: ()-2-amino-3-(4-hydroxy-3-methoxyphenyl)-2-methylpropiononitrile(6555-27-7)

Safety Data

• Hazardous Substances Data: 6555-27-7(Hazardous Substances Data)

Usage

Description

()-2-amino-3-(4-hydroxy-3-methoxyphenyl)-2-methylpropiononitrile, commonly known as amiodarone, is a pharmaceutical compound characterized by its unique chemical structure that includes an amino group, a hydroxy group, a methoxy group, and a nitrile group. These functional groups contribute to its significant pharmacological activity, making it a potent medication for the treatment of irregular heartbeats and specific arrhythmias.

Uses

Used in Cardiology:
Amiodarone is utilized as a class III antiarrhythmic agent in the field of cardiology. It functions by influencing the heart's electrical activity, which helps in stabilizing the heart rhythm. This medication is particularly effective for the treatment of various types of arrhythmias, including atrial fibrillation and ventricular fibrillation.
Due to its long half-life, amiodarone allows for a convenient once-daily dosing regimen, which enhances patient compliance. However, it is essential to administer this medication with caution and under close medical supervision, as it has a relatively high potential for adverse effects and interactions with other medications. This careful approach ensures that the benefits of amiodarone are maximized while minimizing potential risks for patients.

Relevant articles and documents

Synthesis of L-alpha-methyldopa from asymmetric intermediates.

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